NEUROLOGIC ASPECTS OF LYME DISEASE IN NORTH AMERICA

莱姆病是美国一种主要的新发传染病，已经 在公众意识、健康方面成为一个重大的健康问题 护理费用和医疗实践标准。神经学的介入现在是 被公认为莱姆病的主要发病率，但尚未被 以系统的方式进行研究。此计划项目已组装了一个 研究神经学莱姆病的跨学科研究小组。 他们将利用莱姆医院的临床和实验室资源 石溪疾病中心。本计划项目的所有组件均为 通过共享的方法、概念框架和共同核心联系在一起。 这三个临床项目将为发病机制提供材料 项目： 项目1将着眼于宿主因素的作用(T细胞反应)和 生物因素(神经嗜性、抗原性变异)。 项目2将确定以下项目的频率、相关性和结果 早期莱姆病的神经系统侵犯。 项目3将描述慢性莱姆病的神经行为综合征 疾病。 项目4将研究儿童的神经性莱姆病。 支持核心是：A)管理中心核心；B)数据 管理核心；C)中央实验室核心；D)神经心理学核心。 该计划项目的主要科学目标是：1)确定 并前瞻性地描述神经学、神经心理学和 儿童和成人莱姆病的心理社会表现； 探讨神经系统莱姆病的发病机制。 次要目标是3)确定相关脑脊液的特征 改变；以及4)确定不良结局的风险因素。 该计划项目将支持结构化的跨学科工作，以 研究莱姆病的神经学方面。它将提供信息 引导……发展 合理和经济高效的公共卫生政策对这一重要 感染。

Lyme disease is a major emerging infection in the United States, and has become a significant health issue in terms of public awareness, health care costs, and medical practice standards. Neurologic involvement is now recognized as the major morbidity of Lyme disease, but has not been studied in a systematic fashion. This Program Project has assembled an interdisciplinary team of investigators to study neurologic Lyme disease. They will utilize the clinical and laboratory resources of the Lyme Disease Center at Stony Brook. All components of this Program Project are linked by shared methodologies, conceptual frameworks, and common Cores. The three Clinical Projects will provide materials for the Pathogenesis Project: Project 1 will look at the role of host factors (the T cell response) and organism factors (neurotropism, antigenic variation). Project 2 will determine the frequency, correlates, and outcome of central nervous system invasion in early Lyme disease. Project 3 will characterize the neurobehavioral syndromes of chronic Lyme disease. Project 4 will study neurologic Lyme disease in children. The supporting Cores are: A) an Administrative Center Core; B) a Data Management Core; C) a Central Laboratory Core; D) a Neuropsychology Core. The primary scientific goals of this Program Project are 1) to identify and characterize prospectively the neurologic, neuropsychologic, and psychosocial manifestations of Lyme disease in children and adults; and 2) to identify pathogenetic mechanisms involved in neurologic Lyme disease. The secondary goals are 3) to characterize associated cerebrospinal fluid changes; and 4) to identify risk factors for poor outcome. This Program Project will support a structured interdisciplinary effort to study the neurologic aspects of Lyme disease. It will provide information to guide development of rational and cost-effective public health policy for this important infection.