NEUROLOGIC ASPECTS OF LYME DISEASE IN NORTH AMERICA

莱姆病是美国一种主要的新发感染， 成为公众意识、健康等方面的一个重大健康问题 护理费用和医疗实践标准。现在神经系统受累 莱姆病被认为是主要疾病，但尚未得到证实 以系统的方式进行研究。该计划项目汇集了 跨学科研究小组研究神经莱姆病。 他们将利用莱姆病的临床和实验室资源 石溪疾病中心。该计划项目的所有组成部分都是 通过共享方法、概念框架和共同核心联系起来。 这三个临床项目将为发病机制提供材料 项目： 项目 1 将研究宿主因素（T 细胞反应）和 有机体因素（向神经性、抗原变异）。 项目 2 将确定中央研究的频率、相关性和结果 早期莱姆病的神经系统侵袭。 项目 3 将描述慢性莱姆病的神经行为综合征的特征 疾病。 项目 4 将研究儿童神经系统莱姆病。 支持核心是： A) 行政中心核心； B) 数据 管理核心； C) 中央实验室核心； D) 神经心理学核心。 该计划项目的主要科学目标是 1) 确定 并前瞻性地描述神经学、神经心理学和 儿童和成人莱姆病的心理社会表现；和 2) 确定神经莱姆病的发病机制。 次要目标是 3) 表征相关脑脊液 变化； 4) 识别导致不良结果的风险因素。 该计划项目将支持结构化的跨学科努力 研究莱姆病的神经学方面。它将提供信息 来指导发展 针对这一重要问题采取合理且具有成本效益的公共卫生政策 感染。

Lyme disease is a major emerging infection in the United States, and has become a significant health issue in terms of public awareness, health care costs, and medical practice standards. Neurologic involvement is now recognized as the major morbidity of Lyme disease, but has not been studied in a systematic fashion. This Program Project has assembled an interdisciplinary team of investigators to study neurologic Lyme disease. They will utilize the clinical and laboratory resources of the Lyme Disease Center at Stony Brook. All components of this Program Project are linked by shared methodologies, conceptual frameworks, and common Cores. The three Clinical Projects will provide materials for the Pathogenesis Project: Project 1 will look at the role of host factors (the T cell response) and organism factors (neurotropism, antigenic variation). Project 2 will determine the frequency, correlates, and outcome of central nervous system invasion in early Lyme disease. Project 3 will characterize the neurobehavioral syndromes of chronic Lyme disease. Project 4 will study neurologic Lyme disease in children. The supporting Cores are: A) an Administrative Center Core; B) a Data Management Core; C) a Central Laboratory Core; D) a Neuropsychology Core. The primary scientific goals of this Program Project are 1) to identify and characterize prospectively the neurologic, neuropsychologic, and psychosocial manifestations of Lyme disease in children and adults; and 2) to identify pathogenetic mechanisms involved in neurologic Lyme disease. The secondary goals are 3) to characterize associated cerebrospinal fluid changes; and 4) to identify risk factors for poor outcome. This Program Project will support a structured interdisciplinary effort to study the neurologic aspects of Lyme disease. It will provide information to guide development of rational and cost-effective public health policy for this important infection.