REGULATION OF GENE EXPRESSION BY GROWTH HORMONE AND RELATED GROWTH FACTORS

生长激素和相关生长因子对基因表达的调节

• 批准号: 6244557
• 负责人: Jessica Schwartz
• 金额: $ 2.22万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6244557
• 关键词: animal tissue; gene expression; gene induction /repression; growth factor; hormone receptor; protooncogene; somatotropin; tissue /cell culture; transcription factor

Regulation of gene expression by GH is a focus to understand the mechanism of action of GH. In 3T3-F442A cells, GH induces c-fos transcription, via the serum response element (SRE). We are investigating involvement of transcription factors associated with the SRE and with the SIF-binding sequence in GH action. Other approaches include studying signaling between GH receptors and c-fos tyrosine kinase, and assessment of GH action in cells expressing anti-sense c- fos.

生长激素对基因表达的调控是研究生长激素对基因表达调控的一个热点。 GH的作用机制 在3 T3-F442 A细胞中，GH诱导c-fos 通过血清反应元件（SRE）转录。 我们 研究转录因子的参与， SRE和SIF结合序列在GH的作用。 其他方法 包括研究GH受体和c-fos酪氨酸之间信号传导 激酶，并评估表达反义c- fos.