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REGULATION OF GENE EXPRESSION BY GROWTH HORMONE AND RELATED GROWTH FACTORS

REGULATION OF GENE EXPRESSION BY GROWTH HORMONE AND RELATED GROWTH FACTORS
生长激素和相关生长因子对基因表达的调节
批准号：
6244557
负责人：
Jessica Schwartz
金额：
$2.22万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-20 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6244557
关键词：
animal tissue gene expression gene induction /repression growth factor hormone receptor protooncogene somatotropin tissue /cell culture transcription factor

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Regulation of gene expression by GH is a focus to understand the mechanism of action of GH. In 3T3-F442A cells, GH induces c-fos transcription, via the serum response element (SRE). We are investigating involvement of transcription factors associated with the SRE and with the SIF-binding sequence in GH action. Other approaches include studying signaling between GH receptors and c-fos tyrosine kinase, and assessment of GH action in cells expressing anti-sense c- fos.
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