HORMONAL,VISUAL & NEUROPSYCHOLOGIC DYSFUNCTION IN PITUITARY HYPOTHALAMIC DISEASE

该项目的目的是更好地定义发病率，解剖 相关因素、病理生理学、自然史或对治疗的反应 激素、视觉和神经心理功能障碍的患者 肿瘤、头部创伤或涉及垂体的其他病理， 下丘脑 在每个病人身上，一组垂体前叶， 将进行垂体后叶、视觉、神经心理和MRI检查 术前和术后6-24个月，放射学或医疗 疗法 治疗类型将由接受治疗的医生选择。 病人被提到。 功能测试的结果将 结合其他变量进行分析，以确定1） 存在的功能障碍的发生率和类型; 2）它们的相关性（如果有的话） 与MRI上病变位置的关系; 3）它们与 随后的激素、视觉或神经心理学临床紊乱 功能;以及4）它们随时间的变化， 治疗 我们预计，概述的信息将改善 各种类型垂体下丘脑 疾病，也可能是在确定位置的基本价值 和/或调节神经元系统的功能组织 这些重要活动。

The purpose of this project is to better define the incidence, anatomical correlates, pathophysiology, natural history, or response to treatment of hormonal, visual and neuropsychologic dysfunction(s) in patients with tumors, head trauma or other pathology involving the pituitary and hypothalamus. In each patient, a battery of anterior pituitary, posterior pituitary, visual, neuropsychologic and MRI tests will be given before and at 6-24 month intervals after surgical, radiologic or medical therapy. The type of therapy will be chosen by the physician to whom the patient was referred. The results of the functional tests will be analyzed in conjunction with the other variables to determine 1) the incidence and types of dysfunction present; 2) their correlation if any with the location of the lesion on MRI; 3) their relationship to subsequent clinical disturbances of hormonal, visual or neuropsychologic function; and 4) their change over time following different kinds of treatment. We anticipate that the information outlined will improve the management of patients with various types of pituitary hypothalamic disease, and may also be of fundamental value in determining the location and/or functional organization of the neuronal systems that regulate these vital activities.