HORMONAL,VISUAL & NEUROPSYCHOLOGIC DYSFUNCTION IN PITUITARY HYPOTHALAMIC DISEASE

荷尔蒙、视觉

• 批准号: 6304187
• 负责人: Mark Ellis Molitch
• 金额: $ 2.05万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304187
• 关键词: brain disorder chemotherapy; clinical research; endocrine disorder; endocrine gland /system; head /neck injury; human subject; hypothalamic pituitary axis; hypothalamus; neuropsychological tests; neuropsychology; pathology; pituitary neoplasms; vision; vision disorders

The purpose of this project is to better define the incidence, anatomical correlates, pathophysiology, natural history, or response to treatment of hormonal, visual and neuropsychologic dysfunction(s) in patients with tumors, head trauma or other pathology involving the pituitary and hypothalamus. In each patient, a battery of anterior pituitary, posterior pituitary, visual, neuropsychologic and MRI tests will be given before and at 6-24 month intervals after surgical, radiologic or medical therapy. The type of therapy will be chosen by the physician to whom the patient was referred. The results of the functional tests will be analyzed in conjunction with the other variables to determine 1) the incidence and types of dysfunction present; 2) their correlation if any with the location of the lesion on MRI; 3) their relationship to subsequent clinical disturbances of hormonal, visual or neuropsychologic function; and 4) their change over time following different kinds of treatment. We anticipate that the information outlined will improve the management of patients with various types of pituitary hypothalamic disease, and may also be of fundamental value in determining the location and/or functional organization of the neuronal systems that regulate these vital activities.

本项目的目的是更好地确定肿瘤、头部创伤或其他涉及垂体和下丘脑的病理学患者的激素、视觉和神经心理功能障碍的发生率、解剖学相关性、病理生理学、自然史或治疗反应。 在每例患者中，在手术、放射学或药物治疗之前和之后6-24个月间隔时，将进行一系列垂体前叶、垂体后叶、视觉、神经心理学和MRI检查。 治疗类型将由患者转诊的医生选择。 将结合其他变量分析功能测试的结果，以确定1）存在的功能障碍的发生率和类型; 2）它们与MRI上病变位置的相关性（如果有的话）; 3）它们与激素、视觉或神经心理功能的后续临床紊乱的关系;以及4）它们在不同种类的治疗后随时间的变化。 我们预计，所概述的信息将改善各种类型的垂体下丘脑疾病的患者的管理，也可能是在确定的位置和/或功能组织的神经元系统，调节这些重要的活动的基本价值。