HORMONAL,VISUAL & NEUROPSYCHOLOGIC DYSFUNCTION IN PITUITARY HYPOTHALAMIC DISEASE

这个项目的目的是更好地定义发病率、解剖学 相关、病理生理学、自然病史或对治疗的反应 精神分裂症患者的激素、视觉和神经心理障碍(S) 肿瘤、头部创伤或其他累及脑下垂体和 下丘脑。在每个患者中，一组垂体前叶，后叶 脑垂体、视觉、神经心理学和核磁共振检查将在 在手术、放射或内科治疗后间隔6-24个月。 治疗的类型将由患者所在的医生选择 已提交。功能测试的结果将在#年进行分析 与其他变量相结合以确定1)发病率和 存在功能障碍的类型；2)如果有的话，它们与位置的相关性 3)与后续临床的关系 荷尔蒙、视觉或神经心理功能障碍；4)他们 在不同种类的治疗之后，随着时间的推移而变化。我们期待着 概述的信息将改善对患有癌症患者的管理 各种类型的垂体下丘脑疾病，也可能是 在确定位置和/或功能方面的基本价值 调节这些重要活动的神经系统的组织。

The purpose of this project is to better define the incidence, anatomical correlates, pathophysiology, natural history, or response to treatment of hormonal, visual and neuropsychologic dysfunction(s) in patients with tumors, head trauma or other pathology involving the pituiary and hypothalamus. In each patient, a battery of anterior pituitary, posterior pituitary, visual, neuropsychologic and MRI tests will be given before and at 6-24 month intervals after surgical, radiologic or medical therapy. The type of therapy will be chosen by the physician to whom the patient was referred. The results of the functional tests will be analyzed in conjunction with the other variables to determine 1) the incidence and types of dysfunction present; 2) their correlation if any with the location of the lesion on MRI; 3) their relationship to subsequent clinical disturbances of hormonal, visual or neuropsychologic function; and 4) their change over time following different kinds of treatment. We anticipate that the information outlined will improve the management of patients with various types of pituitary hypothalamic disease, and may also be of fundamental value in determining the location and/or functional organization of the neuronal systems that regulate these vital activities.