SEX HORMONES AS RISK FACTORS FOR HEART DISEASE IN WOMEN WITH NIDDM

性激素是 NIDDM 女性心脏病的危险因素

• 批准号: 6245667
• 负责人: MARY KORYTKOWSKI
• 金额: $ 1.76万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-18 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245667
• 关键词: androgens; cardiovascular disorder epidemiology; clinical research; coronary disorder; disease /disorder proneness /risk; family genetics; female; gestational diabetes mellitus; human subject; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; women's health

This study is designed to investigate the hypothesis that women with NIDDM have higher androgens when compared to nondiabetic women, to an enhanced risk for CAD This study will determine whether women at risk for the development of NIDDM (1st degree relative of individuals w/NIDDM, &/or with a history of gestational DM) have an increase in circulating androgens & will identify associations between measures of insulin sensitivity (SI) and cardiovascular risk.

这项研究旨在调查的假设，妇女与 与非糖尿病女性相比，NIDDM女性的雄激素更高， 增加CAD的风险这项研究将确定是否有风险的妇女 NIDDM的发展（患有NIDDM的个体的一级亲属， 和/或有妊娠期糖尿病史）的循环中 雄激素&将确定胰岛素测量之间的关联 敏感性（SI）和心血管风险。