HYPERANDROGENISM AS A RISK FACTOR FOR ATHEROGENESIS IN WOMEN WITH NIDDM

雄激素过多症是 NIDDM 女性动脉粥样硬化的危险因素

• 批准号: 6245617
• 负责人: MARY KORYTKOWSKI
• 金额: $ 1.76万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-18 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245617
• 关键词: adrenal disorder; androgens; atherosclerosis; clinical research; disease /disorder proneness /risk; female; hormone regulation /control mechanism; human subject; noninsulin dependent diabetes mellitus; postmenopause; sex hormones

Cardiovascular morbidity and mortality increase in post-menopausal type II diabetic subjects. This study will evaluate the hypothesis that this increase, known to be associated with circulating lipid abnormalities relates to 1)increasing circulating androgen levels following menopause 2)circulating androgen levels in response to glucose administration in diabetic subjects and 3)the contribution of altered ovarian hormone concentrations.

绝经后类型的心血管疾病发病率和死亡率增加 II型糖尿病患者。 这项研究将评估这一假设， 增加，已知与循环脂质异常相关 涉及1）绝经后循环雄激素水平增加 2)循环雄激素水平对葡萄糖给药的反应 糖尿病受试者和 3)卵巢激素改变 浓度的