EFFECT OF ACUTE AND PROLONGED GLIMEPIRIDE THERAPY ON INSULIN SECRETION

急性和长期格列美脲治疗对胰岛素分泌的影响

• 批准号: 5218353
• 负责人: MARY KORYTKOWSKI
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5218353
• 关键词: blood glucose; clinical research; diabetes mellitus therapy; glucose clamp technique; glucose metabolism; human subject; human therapy evaluation; insulin; noninsulin dependent diabetes mellitus; pancreatic islet function; sulfonylurea

The objective of this study is to determine the mechanism (s) by which an investigational new drug glimepiride, a sulfonylurea, improves glycemic control in NIDDM with specific reference to post absorptive glucose homeostasis. Glimepiride is thought to act by improving both insulin secretion and insulin sensitivity. Diabetic and normal subjects will have overnight hepatic glucose production, hyperglycemic clamp and euglycemic clamp studies done before and after four months of glimepiride.

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