INSULIN HPN & REGULAR PREMIX RATIO 50 & 50 VS PREMIX RATIOS 70 & 30

本研究将研究每5单位常规胰岛素中含有5单位NPH的预混胰岛素制剂(50/50)和胰岛素制剂(70/30)之间的差异。两个12小时的正常血糖钳夹程序将在健康男性身上进行。受试者将盲法皮下注射0.2单位50/50或70/30的胰岛素制剂。20%的葡萄糖将按滴定的剂量注入，以维持正常血糖。主要的疗效测量将是在注射后的头4小时内维持正常血糖所需的葡萄糖输注率的差异。

This study will investigate differences between a premixed insulin preparation containing 5 units NPH for every 5 units regular insulin (50/50) and a (70/30) insulin preparation. Two 12 hour euglycemic clamp procedures will be performed in healthy men. Subjects will receive 0.2 units subcutaneously of the 50/50 or 70/30 insulin preparation in a blinded manner. Twenty percent dextrose will be infused at a dose titrated to maintain euglycemia. The primary efficacy measure will be the difference in glucose infusion rates required to maintain euglycemia during the first 4 hours after injection.