INFANT HEME CATABOLISM AND CARBON MONOXIDE DETECTION

婴儿血红素分解代谢和一氧化碳检测

• 批准号: 6246136
• 负责人: DAVID K STEVENSON
• 金额: $ 3.61万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-15 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246136
• 关键词: bilirubin; biotransformation; blood disorder diagnosis; breath tests; carbon monoxide; clinical research; diagnosis design /evaluation; hemolysis; human subject; infant human (0-1 year); noninvasive diagnosis; patient monitoring device

We continue our development of carbon monoxide (CO)-monitoring technology for laboratory and bedside diagnosis of hemolysis or increased total bilirubin production from other causes. This involves developing and refining instrumentation and techniques or noninvasive diagnosis of hemolysis at the bedside through measurement of excreted CO. We have continued to develop an automatic sampler and analyzer for detection of breath CO, which will be used in a planned trial of a heme analogue inhibition of bilirubin production. Reliability and validity of instrumentation has been the focus of this last year's work.

我们继续开发一氧化碳（CO）监测 溶血或溶血病的实验室和床旁诊断技术 其他原因引起的总胆红素增加。 这涉及 开发和完善仪器和技术， 通过测量排泄物在床边诊断溶血 有限 我们继续开发自动取样器和分析器， 检测呼吸CO，这将用于计划的血红素试验 类似物抑制胆红素的产生。信度和效度 仪器一直是去年工作的重点。