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MUTATION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE LOCUS IN LYMPHOCYTES

MUTATION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE LOCUS IN LYMPHOCYTES
淋巴细胞次黄嘌呤-鸟嘌呤磷酸核糖基转移酶位点的突变
批准号：
6246323
负责人：
JONATHAN B WARD
金额：
$2.71万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-01-06 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6246323
关键词：
biomarker blood chemistry cancer risk clinical research epidemiology gene mutation human genetic material tag human subject hypoxanthine phosphoribosyltransferase lymphocyte mutagens occupational hazard patient monitoring device tobacco abuse toxin metabolism urinalysis

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中文摘要
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英文摘要
The objective is to develop a assay protocol for monitoring human populations to determine whether they have been exposed to mutagenic agents of, in instances where exposure is known, to determine if their exposure to known mutagens is at a sufficient level to produce a biological effect that can be detected as a increase in the frequency of somatic cell mutants. The protocol will be based on the combined use of short & longer term assays for mutation in peripheral blood lymphocytes at the hypoxanthine guanine phosphoribosyl transferase gene locus.
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