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MUTATION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE--LOCUS IN LYMPH

MUTATION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE--LOCUS IN LYMPH
次黄嘌呤-鸟嘌呤磷酸核糖基转移酶--淋巴位点的突变
批准号：
6276401
负责人：
JONATHAN B WARD
金额：
$2.69万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6276401
关键词：
biomarker blood chemistry cancer risk clinical research epidemiology gene mutation human genetic material tag human subject hypoxanthine phosphoribosyltransferase lymphocyte mutagens occupational hazard patient monitoring device tobacco abuse toxin metabolism urinalysis

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中文摘要
翻译
目的是开发一种用于监测人体的测定方案， 人群，以确定他们是否已暴露于诱变 或在已知暴露的情况下，确定其 暴露于已知诱变剂的水平足以产生 生物效应，可以检测到的频率增加， 体细胞突变体该方案将基于联合使用 外周血淋巴细胞突变的短期和长期测定 在次黄嘌呤鸟嘌呤磷酸核糖转移酶基因位点。
英文摘要
The objective is to develop an assay protocol for monitoring human populations to determine whether they have been exposed to mutagenic agents or, in instances where exposure is known, to determine if their exposure to known mutagens is at a sufficient level to produce a biological effect that can be detected as a increase in the frequency of somatic cell mutants. The protocol will be based on the combined use of short and longer term assays for mutation in peripheral blood lymphocytes at the hypoxanthine guanine phosphoribosyl transferase gene locus.
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