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MUTATION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE--LOCUS IN LYMPH

MUTATION OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE--LOCUS IN LYMPH
次黄嘌呤-鸟嘌呤磷酸核糖基转移酶--淋巴位点的突变
批准号:
6276401
负责人:
JONATHAN B WARD
金额:
$2.69万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 1998-11-30

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中文摘要
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英文摘要
The objective is to develop an assay protocol for monitoring human populations to determine whether they have been exposed to mutagenic agents or, in instances where exposure is known, to determine if their exposure to known mutagens is at a sufficient level to produce a biological effect that can be detected as a increase in the frequency of somatic cell mutants. The protocol will be based on the combined use of short and longer term assays for mutation in peripheral blood lymphocytes at the hypoxanthine guanine phosphoribosyl transferase gene locus.
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DEVELOPMENT OF BIOMARKERS TO ASSESS COMMUNITY LEVEL EXPOSURE TO TOXICANTS
HUMAN SENSITIVITY TO GENOTOXIC EFFECTS OF BUTADIENE
HUMAN SENSITIVITY TO GENOTOXIC EFFECTS OF BUTADIENE
9th International Conference on Environmental Mutagens: Student Travel Expenses
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