DEVELOPMENT OF BIOMARKERS TO ASSESS COMMUNITY LEVEL EXPOSURE TO TOXICANTS

开发生物标志物来评估社区水平的有毒物质暴露情况

• 批准号: 7952175
• 负责人: JONATHAN B WARD
• 金额: $ 0.13万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952175
• 关键词: Adverse effects; Air Pollutants; Appearance; Area; Biological; Biological Markers; Biological Markers; Blood; Blood specimen; Chemicals; Clinical; Clinical Research; Communities; Computer Retrieval of Information on Scientific Projects Database; Development; Disadvantaged; Disease; Distant; Environmental Pollutants; Exposure to; Funding; Genetic; Grant; Inflammatory; Institution; Interleukin-6; Interleukin-8; Life; Low income; Measures; Outcome; Oxidative Stress; Population; Research; Research Personnel; Resources; Risk; Sampling; Serum; Social Characteristics; Source; Specimen; Spottings; TNF gene; Thiobarbituric Acid Reactive Substances; Time; Toxic effect; United States National Institutes of Health; Urine; cytokine; pollutant; response; toxicant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biomarkers are biological changes that can be detected in blood, urine or other biological specimens. They can provide indications of exposure to toxic agents at the time of exposures and long before the appearance of clinical disease. There is a need to identify biomarkers that are sensitive enough to detect exposure to low levels of pollutant chemicals that are found in communities. The objective of this study to investigate the sensitivity of biomarkers that detect inflammatory and genetic toxicity responses to environmental pollutant exposures. We hypothesize that a population that resides in a community near major point sources of toxic air pollutants will express changes in biological markers that detect inflammatory and/or genotoxic responses in a quantitatively different way than a demographically similar population living in an area more distant from major sources of toxic air pollutants. We will collect the following samples 1) a blood sample 2) a breath condensate sample and 3) a spot urine sample. The biomarkers to be measured in serum will be the pro-inflammatory cytokines, TNF?, Interleukin-6, and Interleukin-8, oxidative stress measured as Thiobarbituric Acid Reactive Substances (TBARS). The anticipated outcome will be to determine whether this approach is sufficiently sensitive to be useful for the assessment of adverse effects from exposure to community level exposure to toxic air pollutants in the context of cumulative risks related to low income and other characteristics of social disadvantage.

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