Discovery and mechanisms of host cell factors in HIV uncoating

HIV脱壳宿主细胞因子的发现及其机制

• 批准号: nhmrc : GNT1100771
• 负责人: A/Pr Stuart Turville
• 金额: $ 63.51万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovery-mechanisms-host-hiv-uncoating/1346135
• 关键词: Discovery; mechanisms; host; cell; factors

HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.

HIV进入宿主细胞需要释放衣壳，衣壳是保护病毒基因组的蛋白质外壳。衣壳劫持宿主蛋白以保护自己免受细胞防御，同时细胞进化出可以阻止病毒感染的传感器。这项提议旨在发现与宿主和病毒之间的军备竞赛有关的蛋白质，并破译它们如何控制衣壳分解。这一洞察力将有助于设计抗艾滋病毒感染的新药，以及为基因治疗输送基因的新方法。