HIV assembly, transport, egress and transfer from infected dendritic cells

HIV从受感染的树突状细胞组装、运输、流出和转移

• 批准号: nhmrc : 570917
• 负责人: A/Pr Stuart Turville
• 金额: $ 34.12万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hiv-assembly-transport-dendritic-cells/80832
• 关键词: HIV; assembly; transport; egress; transfer

HIV-AIDS is the fourth leading killing disease worldwide, with the disease burden shifting towards women. Study of the HIV life cycle in cells known to be targetted during HIV transmission is key towards designing additional preventative measures in the form of topical gels known as microbicides. Mapping of the basic pathways of viral transport within such cells, will aid further drug discovery and-or appropriateness of use of existing drugs in microbicide formulations.

艾滋病毒/艾滋病是全世界第四大致死疾病，疾病负担向妇女转移。研究艾滋病毒传播过程中已知的靶细胞中的艾滋病毒生命周期是设计额外预防措施的关键，这些措施以被称为杀微生物剂的局部凝胶的形式出现。绘制这些细胞内病毒运输的基本途径将有助于进一步的药物发现和/或在杀微生物剂制剂中使用现有药物的适当性。