HIV-1 transcriptional gene silencing by promoter targeted si/shRNAs: uncovering mechanisms, optimising delivery systems, assessing in vivo efficacy.

通过启动子靶向 si/shRNA 沉默 HIV-1 转录基因：揭示机制、优化递送系统、评估体内功效。

• 批准号: nhmrc : 1049473
• 负责人: A/Pr Stuart Turville
• 金额: $ 42.79万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hiv-1-transcriptional-vivo-efficacy/112087
• 关键词: HIV; transcriptional; gene; silencing; promoter

Current therapy for HIV is effective but must be taken for life. If therapy is stopped the virus comes back immediately from reservoirs not affected by current drugs. These fluctuating levels of virus are associated with increased illness and death. We are exploring a method of inducing prolonged viral latency using short double stranded RNA molecules. We propose to understand the mechanism of action of these possible therapeutics and to develop these constructs towards use in clinical trials.

目前的艾滋病毒治疗是有效的，但必须终身服用。如果停止治疗，病毒会立即从不受当前药物影响的宿主中返回。这些波动的病毒水平与疾病和死亡的增加有关。我们正在探索一种使用短双链RNA分子诱导延长病毒潜伏期的方法。我们建议了解这些可能的疗法的作用机制，并开发这些结构用于临床试验。