HIV-1 transcriptional gene silencing by promoter targeted si/shRNAs: uncovering mechanisms, optimising delivery systems, assessing in vivo efficacy.
HIV-1 transcriptional gene silencing by promoter targeted si/shRNAs: uncovering mechanisms, optimising delivery systems, assessing in vivo efficacy.
批准号:
nhmrc : 1049473
负责人:
A/Pr Stuart Turville
金额:
$42.79万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2016-12-31
中文摘要
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英文摘要
Current therapy for HIV is effective but must be taken for life. If therapy is stopped the virus comes back immediately from reservoirs not affected by current drugs. These fluctuating levels of virus are associated with increased illness and death. We are exploring a method of inducing prolonged viral latency using short double stranded RNA molecules. We propose to understand the mechanism of action of these possible therapeutics and to develop these constructs towards use in clinical trials.
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Solving delivery of gene therapy for control of Human Immunodeficiency Virus infection
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批准号:nhmrc : GNT1128012
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项目类别:Project Grants
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资助金额:$76.54万
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财政年份:2017
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负责人:A/Pr Stuart Turville
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依托单位:
Solving delivery of gene therapy for control of Human Immunodeficiency Virus infection
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批准号:nhmrc : 1128012
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资助金额:$52.23万
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财政年份:2017
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负责人:A/Pr Stuart Turville
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依托单位:
Discovery and mechanisms of host cell factors in HIV uncoating
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批准号:nhmrc : GNT1100771
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项目类别:Project Grants
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资助金额:$63.51万
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财政年份:2016
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负责人:A/Pr Stuart Turville
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依托单位:
Discovery and mechanisms of host cell factors in HIV uncoating
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批准号:nhmrc : 1100771
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项目类别:Project Grants
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资助金额:$43.55万
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财政年份:2016
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负责人:A/Pr Stuart Turville
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依托单位:
Regulation of F-actin during HIV spread
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批准号:nhmrc : 1046703
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项目类别:Project Grants
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资助金额:$37.3万
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财政年份:2013
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负责人:A/Pr Stuart Turville
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依托单位:
Molecular studies of the astrocyte reservoir of HIV-1 in the central nervous system
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批准号:nhmrc : 603708
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项目类别:NHMRC Project Grants
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资助金额:$39.52万
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财政年份:2010
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负责人:A/Pr Stuart Turville
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依托单位:
Dissemmnation of HIV and establishment of cellular reservoirs during transmission
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批准号:nhmrc : 632932
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项目类别:Career Development Fellowships
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资助金额:$26.3万
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财政年份:2010
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负责人:A/Pr Stuart Turville
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依托单位:
HIV assembly, transport, egress and transfer from infected dendritic cells
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批准号:nhmrc : 570917
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项目类别:NHMRC Project Grants
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资助金额:$34.12万
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财政年份:2009
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负责人:A/Pr Stuart Turville
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依托单位:
Kinetics and inhibition of viral transfer from ex vivo derived dendritic cells to CD4 lymphocyte subsets
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批准号:nhmrc : 306708
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项目类别:Early Career Fellowships
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资助金额:$29.74万
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财政年份:2005
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负责人:A/Pr Stuart Turville
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依托单位:
国内基金
海外基金
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