Molecular studies of the astrocyte reservoir of HIV-1 in the central nervous system

中枢神经系统中 HIV-1 星形胶质细胞储存库的分子研究

• 批准号: nhmrc : 603708
• 负责人: A/Pr Stuart Turville
• 金额: $ 39.52万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-studies-astrocyte-central-nervous/100887
• 关键词: Molecular; studies; astrocyte; reservoir; HIV

HIV infects the brain causing dementia in 10-20% patients. Strategies aimed at eradicating HIV infection fail to take into account CNS infection. Understanding the way in which HIV enters, infects and replicates in the brain is pivotal in development of drugs to prevent brain infection and dementia. Our studies have shown that HIV infection of the brain involves mechanisms distinct to those observed for blood and other organs. This study seeks to clarify such mechanisms.

艾滋病毒感染大脑，导致10-20%的患者痴呆。旨在根除艾滋病毒感染的战略没有考虑到中枢神经系统感染。了解艾滋病毒进入、感染和复制大脑的方式对于开发预防大脑感染和痴呆症的药物至关重要。我们的研究表明，艾滋病毒感染大脑涉及的机制与血液和其他器官观察到的机制不同。本研究旨在阐明这些机制。