Discovery of a novel immune evasion strategy employed by mosquito borne viruses to suppress antiviral immune responses

从蚊子、蜱或其他无脊椎动物媒介到人类宿主的转变是成功建立节肢动物传播病毒（虫媒病毒）的关键一步。登革热病毒、西尼罗河病毒、罗斯河病毒等虫媒病毒感染的发病率在世界各地正以惊人的速度增加。此外，新病毒的出现导致人口大量死亡，这是最令人关切的问题。针对这些病毒的疫苗仍然难以捉摸。促成这一点的一个因素是病毒能够制定巧妙的策略来避免或抑制宿主的防御系统，这使得它能够在宿主中成功建立。了解病毒如何逃避-抑制宿主防御机制，肯定会增强和改进我们对抗病毒的方法。在国际上，我们首次发现了虫媒病毒抑制宿主抗病毒免疫反应的新途径。我们已经发现，蚊子细胞衍生的病毒上天然存在的碳水化合物会影响这些病毒逃避-抑制宿主抗病毒蛋白（如干扰素）的能力。这可能是虫媒病毒的一般效应，甚至可能扩展到其他病毒，包括一些致命的病原体（艾滋病毒，流感）。这项研究有可能显着扩大我们对这些病毒如何建立感染和导致疾病的理解。此外，这一发现对理解炎症过程及其调节具有更广泛的意义。

The transition from mosquitoes, ticks, or other invertebrate vectors to the human hosts represents a crucial step in the successful establishment of arthropod borne viruses (arboviruses). The incidence of arbovirus infections such as dengue virus, West Nile virus, Ross River virus is increasing at an alarming rate in various parts of the world. In addition, the emergence of new viruses resulting in significant mortality in the population is of utmost concern. Vaccines for many of these viruses remain elusive. One factor that contributes to this is the ability of viruses to develop ingenious strategies to avoid or suppress the host defence systems, which enable its successful establishment in the host. Understanding how viruses evade-suppress host defence machinery will certainly enhance and improve our approaches to fight them. For the first time internationally we have discovered a new and novel pathway employed by arboviruses to suppress antiviral immune responses in the host. We have discovered that naturally occurring carbohydrates on viruses derived from mosquito cells, would influence these virus s ability to evade-suppress host antiviral proteins such as interferons. This may be a general effect of arboviruses or may even extend to other viruses , which include a number of deadly pathogens (HIV, Influenza). This research has the potential to significantly expand our understanding of how these viruses establish infection and cause disease. Also this discovery has broader implications for understanding inflammatory processes and their regulation.