Improving treatment strategies for chronic alphaviral arthritic diseases

改善慢性甲病毒性关节炎疾病的治疗策略

• 批准号: nhmrc : 1078468
• 负责人: Prof Andreas Suhrbier
• 金额: $ 42.92万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improving-treatment-strategies-arthritic-diseases/518583
• 关键词: Improving; treatment; strategies; chronic; alphaviral

Chikungunya virus and Ross River virus cause epidemics of acute and chronic arthritic disease in humans, which is often poorly managed with current treatments. This grant seeks to understand the mechanisms that give rise to disease in order to identify improved treatment strategies. Both the persistence of viral replication in joint tissues and unnecessary inflammatory responses appear to be important factors driving chronic disease.

基孔肯雅病毒和罗斯河病毒引起人类急性和慢性关节炎疾病的流行，目前的治疗方法往往管理不善。该赠款旨在了解引起疾病的机制，以确定改进的治疗策略。关节组织中病毒复制的持续性和不必要的炎症反应似乎是驱动慢性疾病的重要因素。