Arbovirus activation and modulation of NLRP3 inflammasome

虫媒病毒激活和调节 NLRP3 炎性体

• 批准号: nhmrc : 1079086
• 负责人: Prof Andreas Suhrbier
• 金额: $ 51.99万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/arbovirus-activation-modulation-nlrp3-inflammasome/518629
• 关键词: Arbovirus; activation; modulation; NLRP3; inflammasome

This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.

该项目旨在确定罗斯河和登革热病毒等蚊媒病毒如何与人类宿主相互作用以引起疾病，包括病毒如何逃避宿主的免疫反应以持续存在并长时间引起疾病。了解病毒和宿主免疫系统的差异如何相互作用，导致无症状的严重致残性疾病，将有助于设计新的治疗和预防方案，以减轻这些疾病在澳大利亚的影响。