SYNTHESIS OF SELECTED CHEMICAL CARCINOGENS

本项目的目标是合成、分离、纯化和 若干不同研究目标化合物的表征 致癌研究社区。其中一些化学标准 将是该计划的新成员，其他人将被合成以取代 耗尽的化学品库存。从这次复赛中选出的承包商 将承担两项主要责任。首先，他们将负责 多环芳烃(PAH)衍生物的再合成 (主要是通过既定的程序)补充NCI的库存 必要的化学致癌物参考标准品储存库，以及它们 将开发合成或纯化程序以制备 广谱的其他选定的化学致癌物，化学预防 药剂及其某些代谢物或衍生物。这些类型的 称为多环芳烃代谢物的化合物包括二氢二酚、苯酚、 喹酮、对映体二环氧化物、环氧化物、二醛 邻位双取代含氧衍生物烷基和 羟基烷基取代母烃、共轭衍生物 (化学或生物合成的，如谷胱甘肽、葡萄糖醛酸苷和 硫酸盐)和标记的(~3H、~(13)C、~(4)C)类似物。会议的另一个焦点是 工作范围将包括从选定的致癌物质合成化学品 和化学预防课程。

The goal of this project is the synthesis, isolation, purification, and characterization of a number of different research compounds of interest to the carcinogenesis research community. Some of these chemical standards will be new to the program and others will be synthesized to replace depleted chemical stocks. The contractors selected from this recompetition will have two major responsibilities. First, they will be responsible for the resynthesis of polycyclic aromatic hydrocarbons (PAH)-derivatives (primarily by established procedures) for the restocking of the NCI's Chemical Carcinogen Reference Standards Repository as necessary, and they will develop synthesis or purification procedures for the preparation of a wide spectrum of other selected chemical carcinogens, chemopreventive agents and certain of their metabolites or derivatives. The types of compounds, referred to as PAH metabolites, include dihydrodiols, phenols, quinones, enantiomeric diolepoxides, epoxides, dialdehydes resulting from the cleavage of vicinally-disubstituted oxygenated derivatives, alkyl- and hydroxyalkyl-substituted parent hydrocarbons, conjugated derivatives (chemical or biosynthetic such as glutathiones, glucuronides, and sulfates), and labeled (3H, 13C, 4C) analogs. The other focus of the workscope will include the synthesis of chemicals from selected carcinogen and chemopreventive classes.