SYNTHESIS OF SELECTED CHEMICAL CARCINOGENS

本项目的目标是合成，分离，纯化， 对许多不同的感兴趣的研究化合物进行表征 对致癌研究界的贡献其中一些化学标准 将是新的程序和其他人将被合成，以取代 耗尽的化学品库存。从这次再竞争中选出的承包商 将承担两大责任。 首先，他们将负责 多环芳烃衍生物的再合成 （主要是通过既定程序）重新储存国家癌症研究所的 化学致癌物参考标准储存库（必要时）， 将开发合成或纯化程序，用于制备 广泛的其他选定的化学致癌物，化学预防 药剂及其某些代谢物或衍生物。的类型 被称为PAH代谢物的化合物包括二氢二醇，酚， 醌类、对映体二醇环氧化物、环氧化物、 邻位二取代的含氧衍生物、烷基-和 羟烷基取代的母体烃、共轭衍生物 （化学或生物合成的，如谷胱甘肽、葡萄糖醛酸，和 硫酸盐）和标记的（3 H，13 C，4C）类似物。另一个焦点是 工作范围将包括从选定的致癌物质中合成化学物质 和化学预防类。

The goal of this project is the synthesis, isolation, purification, and characterization of a number of different research compounds of interest to the carcinogenesis research community. Some of these chemical standards will be new to the program and others will be synthesized to replace depleted chemical stocks. The contractors selected from this recompetition will have two major responsibilities. First, they will be responsible for the resynthesis of polycyclic aromatic hydrocarbons (PAH)-derivatives (primarily by established procedures) for the restocking of the NCI's Chemical Carcinogen Reference Standards Repository as necessary, and they will develop synthesis or purification procedures for the preparation of a wide spectrum of other selected chemical carcinogens, chemopreventive agents and certain of their metabolites or derivatives. The types of compounds, referred to as PAH metabolites, include dihydrodiols, phenols, quinones, enantiomeric diolepoxides, epoxides, dialdehydes resulting from the cleavage of vicinally-disubstituted oxygenated derivatives, alkyl- and hydroxyalkyl-substituted parent hydrocarbons, conjugated derivatives (chemical or biosynthetic such as glutathiones, glucuronides, and sulfates), and labeled (3H, 13C, 4C) analogs. The other focus of the workscope will include the synthesis of chemicals from selected carcinogen and chemopreventive classes.