CENTER FOR CLINICAL NETWORK FOR ARDS TREATMENT

ARDS 治疗临床网络中心

• 批准号: 6359464
• 负责人: DAVID Alan SCHOENFELD
• 金额: --
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359464
• 关键词: adult respiratory distress syndrome; cooperative study; critical care; data collection; disease /disorder proneness /risk; human subject; human therapy evaluation; patient care management; respiratory disorder chemotherapy

The Acute Respiratory Distress Syndrome (ARDS) Clinical Network was established as a contract program in 1994 following a national competition. The network has ten clinical centers (composed of 24 hospitals) and one clinical coordinating center. The network was established to hasten the development of effective therapy for ARDS by evaluating new treatments and management practices in a rigorous, controlled setting. The Steering Committee, comprised of network investigators, selects and develops protocols that are reviewed for scientific merit by an independent Protocol Review Committee. Once approved by this committee, the Data Safety and Monitoring Board, that is composed of experts in critical care and pulmonary medicine, statistics, and ethics, advises the institute on conduct of the study, including data quality and analysis, recruitment or other issues faced by the investigators, and human safety concerns. An electronic data collection system and a web site for network investigators were established by the coordinating center to facilitate ease of data management and communication between the hospitals that comprise the ARDS Network. Data quality is carefully monitored at technical site visits and reviews. By conducting careful, controlled clinical trials, the network offers the opportunity for systematic evaluation of new therapies and management practices and also offers a model for clinical investigation in complex studies. As of Summer 2001, the network has completed 3 protocols and is conducting 3 others. An additional 10 centers were added in the fall of 2000 to assist in a study comparing the pulmonary artery catheter vs central venous catheter, and two fluid management strategies in treating acute lung injury and ARDS. Completed studies are: Respiratory Management in Acute Lung Injury and ARDS; Ketoconazaole in Acute Lung Injury and ARDS; and Lisofylline in Acute Lung Injury and ARDS. Studies in progess are: The Late Steroid Rescue Study; Assessment of Low Tidal Volume and Elevated End-Expiratory Volume to Obviate Lung Injury, and The Pulmonary Artery Catheter/Fluid Management Study in Acute Lung Injury and ARDS.

急性呼吸窘迫综合征（ARDS）临床网络， 1994年作为合同项目成立， 竞争 该网络有10个临床中心（由24个 医院）和一个临床协调中心。 该网络是 旨在通过以下方式加速发展有效的ARDS治疗方法： 评估新的治疗方法和管理实践， 控制设置。 指导委员会由网络 研究人员，选择和制定方案， 独立的议定书审查委员会的科学价值。 一旦 经本委员会（数据安全和监测委员会）批准， 是由重症监护和肺医学，统计学， 和伦理，就研究的进行提供建议，包括数据 质量和分析，招聘或其他问题所面临的 调查人员和人类安全问题。 电子数据采集 为网络调查员建立了一个系统和一个网站， 协调中心，以方便数据管理， 医院之间的通信，包括ARDS网络。 在技术现场访问和审查中仔细监测数据质量。 通过 进行仔细的，受控的临床试验，该网络提供了 系统评价新疗法和管理的机会 实践，并为复杂的临床研究提供了一个模型。 问题研究 截至2001年夏季，该网络已完成3个协议， 其他3人进行。 年秋季又增加了10个中心。 2000年协助进行一项比较肺动脉导管与 中心静脉导管和两种液体管理策略在治疗 急性肺损伤和ARDS。 已完成的研究包括：呼吸系统 急性肺损伤和急性呼吸窘迫综合征的处理;酮康唑在急性肺损伤中的应用 急性肺损伤与急性呼吸窘迫综合征及来苏茶碱的临床研究 晚期类固醇补救研究; 低潮气量和呼气末容积升高以使肺消失 受伤， 肺动脉导管/液体管理研究 急性肺损伤和ARDS。