TREATMENT FOR ALCHOLISM: A PRIMATE MODEL

本提案旨在调查酒精中毒的治疗方法，以及在何种情况下这些治疗方法可能证明是最有效的。这些实验包括检验两种药物治疗的有效性，纳曲酮是一种阿片类拮抗剂，布雷马佐辛是一种kappa阿片激动剂，在减少恒河猴口服乙醇的自身剂量方面有效。此外，某些变量可能会影响或影响治疗药物的效果。因此，将调查开放经济与封闭经济对灯盏花素效果的影响。开放的经济允许在赚取的基础上补充乙醇的数量，而在封闭的经济中，受试者赚取全部乙醇。这一范例允许对治疗药物的选择性进行调查。此外，重要的是要了解酒精维持的行为作为性别的函数可能会有什么不同。因此，将研究灯盏花素和纳曲酮对乙醇自我给药的性别影响。

DESCRIPTION This proposal was designed to allow for the investigation of treatments for alcoholism and the conditions under which these treatments may prove most effective. The experiments consist of examining the effectiveness of two pharmacological treatments, naltrexone, an opioid antagonist and bremazocine, a kappa opioid agonist, in reducing self- administration of oral ethanol by rhesus monkeys. Furthermore, it is possible that certain variables may influence may influence the effectiveness of treatment drugs. Therefore, the influence of an open versus closed economy on the effects of bremazocine will be investigated. An open economy allows for supplemented amounts of ethanol in addition to that which is earned, and in a closed economy the subject earns the entire amount. This paradigm allows for the investigation of the selectivity of treatment drugs. In addition, it is important to understand how ethanol-maintained behavior may differ as a function of sex. Thus, the effects of bremazocine and naltrexone on ethanol self-administration as a function of sex will be investigated.