Translational Alcohol Research Program (TARP)

转化酒精研究计划 (TARP)

• 批准号: 10396641
• 负责人: Kelly P Cosgrove
• 金额: $ 28.43万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10396641
• 关键词: alcohol research; programs

The goal of the Translational Alcohol Research Program (TARP) is to facilitate the ability of emerging post-doctoral researchers to bridge the gap in the application of knowledge gained from basic to clinical and social behavioral science research in alcohol use disorders (AUD) and alcohol- related liver disease (ALD). Both AUD and ALD are major public health problems and they should be considered together in the diagnosis and management of alcohol abuse and alcoholism. There is a gap in the application of knowledge f rom basic science studies to clinical models. This is particularly concerning given the establishment of a new generation of approaches (e.g., genomic, whole-body imaging) that allow the application of a `systems' approach to the study of AUD and ALD. It is of critical importance that future investigators are able to exploit these new research tools and approaches to accelerate the discovery and development of new treatments for ALD and AUD. The TARP is designed to improve clinical treatment of AUD and ALD by increasing the availability of appropriately-trained young scientists who are conversant in basic and clinical sciences and able to comfortably traverse the translational gap between these sciences. It is a two-year program offered by the Yale Schools of Medicine and Public Health and provides six post-doctoral trainees the opportunity to devote full-time effort during the initial phase of their careers to developing the skills and experience needed to become independent researchers in the field of translational research in AUD and ALD. The TARP has four main “content areas” viz. Reward Mechanisms; Stress and Negative Affect; Comorbidity (psychiatric and medical); and Alcoholic Liver Disease. The affiliation of TARP faculty with the NIAAA-funded Center for the Translational Neuroscience of Alcoholism and/or the Yale Liver Center enables the TARP trainees to conduct research that readily gravitates between preclinical projects (“bench”) and clinical and population health studies (“bedside” and “community”). Applicants will be MD or PhD post-doctoral candidates, trained in specialties including psychiatry, internal medicine, clinical psychology, public health, epidemiology, pharmacology, toxicology, or neuroscience. The TARP includes: 1) individualized, team- mentored research training, which includes successful completion of a translational-research project, 2) a core curriculum, including seminars on preclinical and clinical research and treatment, the medical consequences of excessive alcohol consumption, hepatology, metabolomics, biostatistics, responsible conduct of scientific research, and grant writing, 3) an individualized training and development plan (including participation in seminars of interest in associated departments and centers), 4) clinical and/or basic science training, and 5) training in effective communication and teaching. Upon completion, TARP graduates will be equipped to establish independent careers in translational research in AUD and ALD.

翻译酒精研究计划（TARP）的目标是促进 新兴的博士后研究人员，以弥合差距，在应用知识，从 酒精使用障碍（AUD）和酒精的临床和社会行为科学研究的基础- 相关肝病（ALD）。AUD和ALD都是主要的公共卫生问题， 在酒精滥用和酒精中毒的诊断和管理中一起考虑。存在间隙 将基础科学研究的知识应用于临床模型。这是特别 考虑到新一代方法的建立（例如，基因组的、全身的 成像），允许应用“系统”方法研究AUD和ALD。是至关 重要的是，未来的研究人员能够利用这些新的研究工具和方法， 加速ALD和AUD新疗法的发现和开发。问题资产救助计划旨在 通过增加受过适当培训的年轻人的可用性来改善AUD和ALD的临床治疗 熟悉基础和临床科学的科学家，能够轻松地穿越 这些科学之间的翻译差距。这是一个为期两年的项目，由耶鲁大学商学院提供， 医学和公共卫生，并提供了六个博士后学员的机会，全职投入 在他们职业生涯的初始阶段，努力发展成为一名合格的教师所需的技能和经验。 在AUD和ALD的转化研究领域的独立研究人员。问题资产救助计划有四个主要方面 “内容领域”，即奖励机制;压力和负面影响;共病（精神和 医学）;和酒精性肝病。TARP教师与NIAAA资助的 酒精中毒的转化神经科学和/或耶鲁肝脏中心使TARP学员能够 开展易于在临床前项目（“实验室”）和临床及人群之间转移的研究 健康研究（“床边”和“社区”）。申请人将是MD或PhD博士后候选人， 接受过精神病学、内科学、临床心理学、公共卫生等专业的培训， 流行病学、药理学、毒理学或神经科学。TARP包括：1）个性化，团队- 指导研究培训，其中包括成功完成一个军事研究项目，2）a 核心课程，包括临床前和临床研究和治疗研讨会，医学 过量饮酒的后果，肝脏学，代谢组学，生物统计学，负责任 进行科学研究和撰写补助金，3）个性化的培训和发展计划 （包括参加相关部门和中心感兴趣的研讨会），4）临床和/或 基础科学训练; 5）有效沟通和教学训练。完成后，TARP 毕业生将有能力在AUD和ALD的翻译研究中建立独立的职业生涯。