Translational Alcohol Research Program (TARP)

翻译酒精研究计划(TARP)的目标是促进 正在涌现的博士后研究人员，以弥合应用从 酒精使用障碍(AUD)和酒精的临床和社会行为科学研究的基础- 相关肝病(ALD)。AUD和ALD都是主要的公共卫生问题，它们应该 在酒精滥用和酒精中毒的诊断和管理中一并考虑。有一个缺口 将基础科学研究中的知识应用于临床模型。这是特别的 关于建立新一代方法(例如，基因组、全身 成像)，允许应用“系统”方法来研究AUD和ALD。这件事很关键 未来的研究人员能够利用这些新的研究工具和方法来 加快发现和开发治疗ALD和AUD的新疗法。问题资产救助计划旨在 通过增加接受过适当培训的年轻人的可用性来改善AUD和ALD的临床治疗 精通基础和临床科学并能够轻松穿越 这些科学之间的翻译鸿沟。这是一个由耶鲁大学提供的为期两年的课程。 并为6名博士后实习生提供了全职投入的机会 在职业生涯的初始阶段努力发展成为 澳大利亚和澳大利亚翻译研究领域的独立研究人员。问题资产救助计划有四个主要方面 “内容区”，即。奖励机制；压力和消极情绪；共病(精神病和 医学)；和酒精性肝病。TARP教职员工与NIAAA资助的 酒精中毒的翻译神经科学和/或耶鲁大学肝脏中心使TARP受训人员能够 开展容易在临床前项目(“BASE”)与临床和人群之间吸引的研究 健康研究(“床边”和“社区”)。申请人将是医学博士或博士后候选人， 受过精神病学、内科、临床心理学、公共卫生、 流行病学、药理学、毒理学或神经科学。TARP包括：1)个性化、团队- 有指导的研究培训，包括成功完成翻译研究项目，2)a 核心课程，包括关于临床前和临床研究和治疗的研讨会，医学 过度饮酒的后果，肝脏学，代谢组学，生物统计学，负责 进行科学研究和撰写赠款；3)制定个性化的培训和发展计划 (包括参加相关科室和中心感兴趣的研讨会)，4)临床和/或 基础科学培训；5)有效沟通和教学培训。完成后，TARP 毕业生将有能力在澳大利亚和澳大利亚的翻译研究领域建立独立的职业生涯。

The goal of the Translational Alcohol Research Program (TARP) is to facilitate the ability of emerging post-doctoral researchers to bridge the gap in the application of knowledge gained from basic to clinical and social behavioral science research in alcohol use disorders (AUD) and alcohol- related liver disease (ALD). Both AUD and ALD are major public health problems and they should be considered together in the diagnosis and management of alcohol abuse and alcoholism. There is a gap in the application of knowledge f rom basic science studies to clinical models. This is particularly concerning given the establishment of a new generation of approaches (e.g., genomic, whole-body imaging) that allow the application of a `systems' approach to the study of AUD and ALD. It is of critical importance that future investigators are able to exploit these new research tools and approaches to accelerate the discovery and development of new treatments for ALD and AUD. The TARP is designed to improve clinical treatment of AUD and ALD by increasing the availability of appropriately-trained young scientists who are conversant in basic and clinical sciences and able to comfortably traverse the translational gap between these sciences. It is a two-year program offered by the Yale Schools of Medicine and Public Health and provides six post-doctoral trainees the opportunity to devote full-time effort during the initial phase of their careers to developing the skills and experience needed to become independent researchers in the field of translational research in AUD and ALD. The TARP has four main “content areas” viz. Reward Mechanisms; Stress and Negative Affect; Comorbidity (psychiatric and medical); and Alcoholic Liver Disease. The affiliation of TARP faculty with the NIAAA-funded Center for the Translational Neuroscience of Alcoholism and/or the Yale Liver Center enables the TARP trainees to conduct research that readily gravitates between preclinical projects (“bench”) and clinical and population health studies (“bedside” and “community”). Applicants will be MD or PhD post-doctoral candidates, trained in specialties including psychiatry, internal medicine, clinical psychology, public health, epidemiology, pharmacology, toxicology, or neuroscience. The TARP includes: 1) individualized, team- mentored research training, which includes successful completion of a translational-research project, 2) a core curriculum, including seminars on preclinical and clinical research and treatment, the medical consequences of excessive alcohol consumption, hepatology, metabolomics, biostatistics, responsible conduct of scientific research, and grant writing, 3) an individualized training and development plan (including participation in seminars of interest in associated departments and centers), 4) clinical and/or basic science training, and 5) training in effective communication and teaching. Upon completion, TARP graduates will be equipped to establish independent careers in translational research in AUD and ALD.