Translational Alcohol Research Program (TARP)

转化酒精研究计划 (TARP)

基本信息

批准号：
10621155
负责人：
Kelly P Cosgrove
金额：
$ 33.67万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10621155
关键词：
alcohol research programs

项目摘要

The goal of the Translational Alcohol Research Program (TARP) is to facilitate the ability of emerging post-doctoral researchers to bridge the gap in the application of knowledge gained from basic to clinical and social behavioral science research in alcohol use disorders (AUD) and alcohol- related liver disease (ALD). Both AUD and ALD are major public health problems and they should be considered together in the diagnosis and management of alcohol abuse and alcoholism. There is a gap in the application of knowledge f rom basic science studies to clinical models. This is particularly concerning given the establishment of a new generation of approaches (e.g., genomic, whole-body imaging) that allow the application of a `systems' approach to the study of AUD and ALD. It is of critical importance that future investigators are able to exploit these new research tools and approaches to accelerate the discovery and development of new treatments for ALD and AUD. The TARP is designed to improve clinical treatment of AUD and ALD by increasing the availability of appropriately-trained young scientists who are conversant in basic and clinical sciences and able to comfortably traverse the translational gap between these sciences. It is a two-year program offered by the Yale Schools of Medicine and Public Health and provides six post-doctoral trainees the opportunity to devote full-time effort during the initial phase of their careers to developing the skills and experience needed to become independent researchers in the field of translational research in AUD and ALD. The TARP has four main “content areas” viz. Reward Mechanisms; Stress and Negative Affect; Comorbidity (psychiatric and medical); and Alcoholic Liver Disease. The affiliation of TARP faculty with the NIAAA-funded Center for the Translational Neuroscience of Alcoholism and/or the Yale Liver Center enables the TARP trainees to conduct research that readily gravitates between preclinical projects (“bench”) and clinical and population health studies (“bedside” and “community”). Applicants will be MD or PhD post-doctoral candidates, trained in specialties including psychiatry, internal medicine, clinical psychology, public health, epidemiology, pharmacology, toxicology, or neuroscience. The TARP includes: 1) individualized, team- mentored research training, which includes successful completion of a translational-research project, 2) a core curriculum, including seminars on preclinical and clinical research and treatment, the medical consequences of excessive alcohol consumption, hepatology, metabolomics, biostatistics, responsible conduct of scientific research, and grant writing, 3) an individualized training and development plan (including participation in seminars of interest in associated departments and centers), 4) clinical and/or basic science training, and 5) training in effective communication and teaching. Upon completion, TARP graduates will be equipped to establish independent careers in translational research in AUD and ALD.

转化酒精研究计划（TARP）的目标是促进新兴的博士后研究人员弥合了从中获得的知识的差距酒精使用障碍（AUD）和酒精的临床和社会行为科学研究基础相关肝病（ALD）。 AUD和ALD都是主要的公共卫生问题，应该是在诊断和管理酒精滥用和酒精中毒中一起考虑。有差距在将基础科学研究中的知识应用于临床模型中。尤其是关注建立新一代方法（例如，基因组，全身成像）允许将“系统”方法应用于AUD和ALD的研究。这很关键重要的是未来的研究人员能够探索这些新的研究工具和方法加速ALD和AUD的新疗法的发现和开发。篷布设计为通过增加适当训练的年轻人的可用性来改善AUD和ALD的临床治疗对基础科学和临床科学感到困惑并能够舒适地穿越的科学家这些科学之间的翻译差距。这是一项为期两年的计划，由耶鲁大学的学校提供医学和公共卫生，并为六名博士后学员提供了专职的机会在他们职业生涯的初期努力，以发展成为所需的技能和经验 AUD和ALD转化研究领域的独立研究人员。篷布有四个主要 “内容区域”。奖励机制；压力和负面影响；合并症（精神病和医疗的）;和酒精性肝病。 TARP教职员工与NIAAA资助的中心酒精中毒和/或耶鲁肝脏中心的转化神经科学使篷布训练能够进行临床前项目（“板凳”）与临床和人群之间很容易吸引的研究健康研究（“床边”和“社区”）。申请人将是医学博士或博士后候选人，经过精神病学，内科，临床心理学，公共卫生，包括专业培训，流行病学，药理学，毒理学或神经科学。篷布包括：1）个性化的团队 - 指导的研究培训，其中包括成功完成翻译研究项目，2）核心课程，包括有关临床前和临床研究和治疗的半手，医学过度饮酒，肝病学，代谢组学，生物统计学，负责任的后果进行科学研究和授予写作，3）个性化的培训和发展计划（包括参与相关部门和中心的感兴趣的半岛），4）临床和/或基础科学培训以及5）有效的沟通和教学培训。完成后，篷布毕业生将等同于在AUD和ALD的转化研究中建立独立的职业。