MEASUREMENT OF AIRWAY TRANSEPITHELIAL POTENTIAL DIFFERENCE IN CYSTIC FIBROSIS

囊性纤维化气道上皮电位差的测量

• 批准号: 6217984
• 负责人: Michael R Knowles
• 金额: $ 0.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6217984
• 关键词: acid base balance; amiloride; clinical research; cystic fibrosis; electrodes; electrolytes; human subject; human therapy evaluation; inhalation drug administration; respiratory disorder chemotherapy; respiratory epithelium; respiratory therapy; secretion; sodium

This study is designed to examine the composition of airway secretions and the bioelectric properties of respiratory epithelium in cystic fibrosis patients, disease control patients and normal subjects. The composition of airway secretions is determined by measuring the volume, electrolyte composition and pH of airway surface liquid before and after aerosol amiloride administration. Studies using a sodium selective electrode were recently added to this study.

本研究旨在检测囊性纤维化患者、疾病对照患者和正常人气道分泌物的组成和呼吸上皮的生物电特性。 通过测量气雾剂阿米洛利给药前后气道表面液体的体积、电解质组成和pH来确定气道分泌物的组成。 最近在这项研究中增加了使用钠选择性电极的研究。