ASSOCIATION OF GENOTYPE AND CIRCULATING LEVELS OF TGF?1 IN CYSTIC FIBROSIS PA

囊性纤维化 PA 中 TGF?1 基因型与循环水平的关联

• 批准号: 7716894
• 负责人: Michael R Knowles
• 金额: $ 1.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716894
• 关键词: Blood specimen; Clinic; Computer Retrieval of Information on Scientific Projects Database; Cystic Fibrosis; Funding; Genes; Genetic Polymorphism; Genotype; Grant; Immune; Institution; Lead; Measures; Purpose; Registries; Research; Research Personnel; Resources; Role; Sampling; Source; United States National Institutes of Health; Wound Healing; cystic fibrosis patients; therapeutic target; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to measure and compare levels of TGF¿1 in cystic fibrosis patients and healthy control subjects. TGF¿1 has been implicated as a potential immune modulator in CF patients with certain genotypes (results from GCRC #1774) and has been shown to alter wound repair. This study is being done to further characterize what differences (if any) exist between circulating TGF¿1 levels in CF patients with two different genotypes and in addition, to describe TGF¿1 levels in normal volunteers. The initial blood samples used to determine genotype will come from samples already collected under GCRC #1774 ?Gene Modifier Study? and the normal volunteer samples will be requested from the Environmental Polymorphisms Registry (GCRC #2140). Both groups of subjects will then be asked to come to either the GCRC or the CF clinic to have a single 35 ml blood sample drawn to measure TGF¿1 levels. A clearer understanding of the potential role of TGF¿1 may lead to further studies as a potential therapeutic target for CF.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是测量和比较囊性纤维化患者和健康对照受试者的TGF-β 1水平。转化生长因子1已经被认为是具有某些基因型的CF患者中的潜在免疫调节剂（来自GCRC #1774的结果），并且已经显示改变伤口修复。 这项研究正在进行，以进一步表征两种不同基因型CF患者的循环TGF <$1水平之间存在的差异（如果有的话），并描述正常志愿者的TGF <$1水平。 用于确定基因型的初始血液样本将来自已根据GCRC #1774采集的样本？基因改造研究？正常志愿者样本将从环境多态性登记处（GCRC#2140）获得。 然后，要求两组受试者前往GCRC或CF诊所，采集35 ml血液样本，以测量TGF β 1水平。更清楚地了解TGF β 1的潜在作用可能会导致进一步的研究作为CF的潜在治疗靶点。