ASSOCIATION OF GENOTYPE AND CIRCULATING LEVELS OF TGF?1 IN CYSTIC FIBROSIS PA
囊性纤维化 PA 中 TGF?1 基因型与循环水平的关联
基本信息
- 批准号:7716894
- 负责人:
- 金额:$ 1.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-04-02 至 2008-05-31
- 项目状态:已结题
- 来源:
- 关键词:Blood specimenClinicComputer Retrieval of Information on Scientific Projects DatabaseCystic FibrosisFundingGenesGenetic PolymorphismGenotypeGrantImmuneInstitutionLeadMeasuresPurposeRegistriesResearchResearch PersonnelResourcesRoleSamplingSourceUnited States National Institutes of HealthWound Healingcystic fibrosis patientstherapeutic targetvolunteer
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The purpose of this study is to measure and compare levels of TGF¿1 in cystic fibrosis patients and healthy control subjects. TGF¿1 has been implicated as a potential immune modulator in CF patients with certain genotypes (results from GCRC #1774) and has been shown to alter wound repair. This study is being done to further characterize what differences (if any) exist between circulating TGF¿1 levels in CF patients with two different genotypes and in addition, to describe TGF¿1 levels in normal volunteers. The initial blood samples used to determine genotype will come from samples already collected under GCRC #1774 ?Gene Modifier Study? and the normal volunteer samples will be requested from the Environmental Polymorphisms Registry (GCRC #2140). Both groups of subjects will then be asked to come to either the GCRC or the CF clinic to have a single 35 ml blood sample drawn to measure TGF¿1 levels. A clearer understanding of the potential role of TGF¿1 may lead to further studies as a potential therapeutic target for CF.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
本研究的目的是测量和比较囊性纤维化患者和健康对照受试者的TGF-β 1水平。转化生长因子1已经被认为是具有某些基因型的CF患者中的潜在免疫调节剂(来自GCRC #1774的结果),并且已经显示改变伤口修复。 这项研究正在进行,以进一步表征两种不同基因型CF患者的循环TGF <$1水平之间存在的差异(如果有的话),并描述正常志愿者的TGF <$1水平。 用于确定基因型的初始血液样本将来自已根据GCRC #1774采集的样本?基因改造研究?正常志愿者样本将从环境多态性登记处(GCRC#2140)获得。 然后,要求两组受试者前往GCRC或CF诊所,采集35 ml血液样本,以测量TGF β 1水平。更清楚地了解TGF β 1的潜在作用可能会导致进一步的研究作为CF的潜在治疗靶点。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael R Knowles其他文献
IMPAIRMENT OF NASAL Na+ TRANSPORT IN VERY PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS). • 1982
呼吸窘迫综合征(RDS)极低出生体重儿鼻 Na+转运受损。•1982 年
- DOI:
10.1203/00006450-199604001-02006 - 发表时间:
1996-04-01 - 期刊:
- 影响因子:3.100
- 作者:
C. W Gowen;Pierre M Barker;Michael R Knowles - 通讯作者:
Michael R Knowles
Michael R Knowles的其他文献
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{{ truncateString('Michael R Knowles', 18)}}的其他基金
Molecular Phenotypes for Cystic Fibrosis Lung Disease
囊性纤维化肺病的分子表型
- 批准号:
7691761 - 财政年份:2008
- 资助金额:
$ 1.02万 - 项目类别:
GENETIC DISORDERS OF MUCOCILIARY CLEARANCE: RARE DISEASES: PCD, CF, & PHA
粘膜纤毛间隙遗传性疾病:罕见疾病:PCD、CF、
- 批准号:
7724741 - 财政年份:2008
- 资助金额:
$ 1.02万 - 项目类别:
Molecular Phenotypes for Cystic Fibrosis Lung Disease
囊性纤维化肺病的分子表型
- 批准号:
8109359 - 财政年份:2008
- 资助金额:
$ 1.02万 - 项目类别:
GENETIC MUTATIONS IN PATIENTS WITH PRIMARY CILIARY DYSKINESIA AND FAMILY
原发性纤毛运动障碍患者及其家族的基因突变
- 批准号:
7716746 - 财政年份:2008
- 资助金额:
$ 1.02万 - 项目类别:
Molecular Phenotypes for Cystic Fibrosis Lung Disease
囊性纤维化肺病的分子表型
- 批准号:
7903160 - 财政年份:2008
- 资助金额:
$ 1.02万 - 项目类别:
GENETIC DISORDERS OF MUCOCILIARY CLEARANCE: RARE DISEASES: PCD, CF, & PHA
粘膜纤毛间隙遗传性疾病:罕见疾病:PCD、CF、
- 批准号:
7622820 - 财政年份:2007
- 资助金额:
$ 1.02万 - 项目类别:
GENETIC MUTATIONS IN PATIENTS WITH PRIMARY CILIARY DYSKINESIA AND FAMILY
原发性纤毛运动障碍患者及其家族的基因突变
- 批准号:
7625498 - 财政年份:2006
- 资助金额:
$ 1.02万 - 项目类别:
MEASUREMENT OF AIRWAY TRANSEPITHELIAL POTENTIAL DIFFERENCE IN CF
CF 气道上皮电位差的测量
- 批准号:
7625491 - 财政年份:2006
- 资助金额:
$ 1.02万 - 项目类别:
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