ACTIVE IMMUNOTHERAPY FOR PATIENTS WITH ANAPLASTIC GLIOMA

间变性神经胶质瘤患者的主动免疫治疗

• 批准号: 6113790
• 负责人: STEVEN K GUDEMAN
• 金额: $ 1.58万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6113790
• 关键词: carmustine; clinical research; clinical trials; combination cancer therapy; glioma; human subject; human therapy evaluation; immunomodulators; levamisole; neoplasm /cancer chemotherapy; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; tissue /cell culture

This is a study of the antitumor effect of active immunization with a tissue culture glioma cell preparation mixed with adjuvant. Patients were randomized to receive immunization with frozen or unfrozen U-251 glioma cells and treated with levamisole, radiotherapy, and BCNU, or treated conventionally with radiotherapy and BCNU.

本研究旨在探讨用抗肿瘤药物A. 与佐剂混合的组织培养胶质瘤细胞制剂。 患者 随机接受冷冻或未冷冻U-251免疫 神经胶质瘤细胞并用左旋咪唑、放疗和BCNU治疗，或 常规放疗加卡氮芥治疗。