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PHASE I SINGLE DOSE TRIAL OF PEITC (PHENETHYL ISOTHIOCYANATE)

PHASE I SINGLE DOSE TRIAL OF PEITC (PHENETHYL ISOTHIOCYANATE)
PEITC（异硫氰酸苯乙酯）的 I 期单剂量试验
批准号：
6264624
负责人：
LEONARD F LIEBES
金额：
$2.1万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264624
关键词：
antineoplastics chemoprevention clinical research clinical trial phase I dosage drug screening /evaluation enzyme linked immunosorbent assay human subject isothiocyanates pharmacokinetics polymerase chain reaction smoking smoking cessation tobacco abuse

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中文摘要
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英文摘要
Phenethyl Isothiocyanate (PEITC) is a naturally occurring compound found in cruciferous vegetables. It has been shown in the laboratory and in rats to inhibit 4-(methynitrosoamino)-1-(3-pyridyl)-1-butanone or NNK, a potent carcinogen in cigarette smoke. This Phase I study will determine the maximum tolerated single dose of PEITC; measure the PK of PEITC to predict the daily dosing interval required to maintain a steady state of PEITC in the hours of NNK exposure; and obtain preliminary data on the perturbation of NKK metabolism by PEITC in human beings. The Core Laboratory was utilized for PCR, ELISA and recombinant DNA techniques.
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Core Clinical Lab
CORE--CLINICAL LABORATORY FACILITY
CORE--CLINICAL LABORATORY FACILITY
PHASE I SINGLE DOSE TRIAL OF PEITC (PHENETHYL ISOTHIOCYANATE)
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