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STEROIDOGENESIS IN HYPERANDROGENISM

STEROIDOGENESIS IN HYPERANDROGENISM
雄激素过多症中的类固醇生成
批准号：
6115516
负责人：
SELMA FELDMAN WITCHEL
金额：
$2.06万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115516
关键词：
adrenal disorder adrenal glands adrenocorticotropic hormone androgens chorionic gonadotropin clinical research female gene mutation genotype human subject molecular genetics ovary ovary disorder phenotype steroid biosynthesis steroid hormone metabolism

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中文摘要
翻译
本建议的目的是确定与多囊卵巢综合征（PCOS）发展相关的激素和遗传因素。多囊卵巢综合征的典型特征在青春期前后变得明显。这项研究有三个主要目标。首先是确定早孕的自然历史。二是确定多囊卵巢综合征中LH/FSH比值升高的成因。第三是确定与多囊卵巢综合征风险增加有关的遗传标记。
英文摘要
The goals of this proposal are to identify hormonal and genetic factors which are associated with the development of polycystic ovary syndrome (PCOS). The typical features of PCOS become conspicuous during the peri-pubertal period. There are three major goals of this study. The first is to determine the natural history of premature pubarche. The second is to determine the ontogeny of the increased LH/FSH ratio in PCOS. And, the third is to identify genetic markers associated with an increased risk to develop PCOS.
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会议论文
STUDIES OF ABNORMAL SEXUAL DIFFERENTIATION AND DEVELOPMENT:SERUM INHIBIN B & FSH
STEROIDOGENESIS IN HYPERANDROGENISM
EVALUATION & TREATMENT OF ABNORMALITIES OF GONADAL OR PUBERTAL DEVELOPMENT
MOLECULAR DIAGNOSIS OF CONGENITAL ADRENAL HYPERPLASIA: PHENOTYPE/GENOTYPE
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