STEROIDOGENESIS IN HYPERANDROGENISM

雄激素过多症中的类固醇生成

• 批准号: 6115516
• 负责人: SELMA FELDMAN WITCHEL
• 金额: $ 2.06万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115516
• 关键词: adrenal disorder; adrenal glands; adrenocorticotropic hormone; androgens; chorionic gonadotropin; clinical research; female; gene mutation; genotype; human subject; molecular genetics; ovary; ovary disorder; phenotype; steroid biosynthesis; steroid hormone metabolism

The goals of this proposal are to identify hormonal and genetic factors which are associated with the development of polycystic ovary syndrome (PCOS). The typical features of PCOS become conspicuous during the peri-pubertal period. There are three major goals of this study. The first is to determine the natural history of premature pubarche. The second is to determine the ontogeny of the increased LH/FSH ratio in PCOS. And, the third is to identify genetic markers associated with an increased risk to develop PCOS.

该提案的目标是确定与多囊卵巢综合征（PCOS）发展相关的激素和遗传因素。 PCOS的典型特征在围青春期变得明显。 这项研究有三个主要目标。 第一个是确定阴毛过早的自然史。 第二是确定PCOS中LH/FSH比值升高的个体发生。第三是确定与PCOS风险增加相关的遗传标记。