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STEROIDOGENESIS IN HYPERANDROGENISM

STEROIDOGENESIS IN HYPERANDROGENISM
雄激素过多症中的类固醇生成
批准号：
6276750
负责人：
SELMA FELDMAN WITCHEL
金额：
$1.51万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6276750
关键词：
adrenal disorder adrenal glands adrenocorticotropic hormone androgens chorionic gonadotropin clinical research female gene mutation genotype human subject molecular genetics ovary ovary disorder phenotype steroid biosynthesis steroid hormone metabolism

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中文摘要
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英文摘要
To clarify the role of adrenal and ovarian steroidogenesis in the pathophysiology of the phenotype associated with chronic anovulatory hyperandrogenism. In this protocol, ACTH and hCG stimulation tests are used to determine androgen production from the adrenal and ovary, respectively. Molecular genetic studies performed to determine if patients carry mutations in the genes encoding steroidogenic enzymes. These studies are the basis for phenotype/genotype correlations in chronic anovulatory hyperandrogenism. FSIVGTT are being added to obtain an insulin resistance phenotype. The otogeny of the increased LH/FSH ratio is being studied.
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会议论文
STUDIES OF ABNORMAL SEXUAL DIFFERENTIATION AND DEVELOPMENT:SERUM INHIBIN B & FSH
STEROIDOGENESIS IN HYPERANDROGENISM
EVALUATION & TREATMENT OF ABNORMALITIES OF GONADAL OR PUBERTAL DEVELOPMENT
MOLECULAR DIAGNOSIS OF CONGENITAL ADRENAL HYPERPLASIA: PHENOTYPE/GENOTYPE
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