TOTAL ENERGY EXPENDITURE IN CYSTIC FIBROSIS

囊性纤维化的总能量消耗

• 批准号: 6291074
• 负责人: CATHERINE LEITCH
• 金额: $ 0.04万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6291074
• 关键词: bioenergetics; child (0-11); clinical research; cystic fibrosis; developmental nutrition; human subject; nutrient requirement; nutrition related tag

We will measure resting energy expenditure and total energy expenditure in 10-12 month old infants and 7- 8 year old children with cystic fibrosis. These two groups have very different physical activity patterns. Infants are not yet ambulatory, so if their resting energy expenditures are higher than those of healthy infants, they are unable to compensate by lowering their physical activity. Therefore, their actual total energy needs may be much higher than those of healthy infants. In contrast, children may compensate for higher resting energy expenditure by decreased physical activity. However, the extent of this compensation is unknown. Knowledge of the total energy expenditures of these patients is necessary to accurately gauge their energy requirements. Our long-term objective is to gain insight into the total energy needs of CF patients in order to provide appropriate nutritional support. The information obtained in this project will provide us with a valuable foundation from which to design future dietary therapies. While early and appropriate dietary intervention is important in CF patients of any age, it is crucial in infants and children who are still growing and developing.

我们将测量患有囊性纤维化的10-12个月大婴儿和7- 8岁儿童的静息能量消耗和总能量消耗。这两个群体有非常不同的身体活动模式。 婴儿还不能走动，所以如果他们的静息能量消耗高于健康婴儿，他们无法通过减少体力活动来补偿。 因此，他们的实际总能量需求可能远远高于健康婴儿。 相反，儿童可能会通过减少体力活动来补偿较高的静息能量消耗。 然而，这种补偿的程度是未知的。了解这些患者的总能量消耗是准确衡量其能量需求所必需的。 我们的长期目标是深入了解CF患者的总能量需求，以便提供适当的营养支持。 本项目所获得的信息将为我们设计未来的饮食疗法提供有价值的基础。 虽然早期和适当的饮食干预对任何年龄的CF患者都很重要，但对仍在生长发育的婴儿和儿童至关重要。