ENERGY REQUIREMENTS OF CRITICALLY ILL NEWBORNS

危重新生儿的能量需求

• 批准号: 6291002
• 负责人: CATHERINE LEITCH
• 金额: $ 1.7万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6291002
• 关键词: acute disease /disorder; bioenergetics; body weight; clinical research; gestational age; human subject; low birth weight infant human; newborn human (0-6 weeks); nutrition related tag

Optimal nutrition for the very low birthweight infant has yet to be established. Current recommendations for weight gain are based on in utero accretion rates without knowledge of exact energy requirements in these infants. Additional stressors are placed on both the ill preterm and term infants above their stable counterparts. Because of this, there has been a general consensus that the energy expenditure of these infants is correspondingly increased. Current studies to evaluate this issue have focused on older chronically ventilated infants rather then infants in the acute stages of illness. While some studies suggest a trend toward increased metabolic requirements, others suggest that current methods of calculating energy expenditure are inadequate and may be overestimating needs. We propose to measure total energy expenditure in term and preterm infants using the doubly labeled water method. We hypothesize that the energy expenditure of ill preterm and term infants will be greater than that of their stable counterparts. We hope to more accurately assess the energy expenditure of these infants and with the information obtained structure more appropriate recommendations for energy intake based on gestational age and presence or absence of illness

极低出生体重儿的最佳营养还有待于 确立了习 目前对体重增加的建议是基于 子宫吸积率没有确切的能量需求的知识， 这些婴儿。 额外的压力被放置在两个生病的早产儿 和足月婴儿的比例高于稳定期婴儿。 因为这个， 人们普遍认为这些婴儿的能量消耗 也相应增加。 目前评估这一问题的研究有 重点关注年龄较大的长期通气婴儿，而不是 疾病的急性期。 虽然一些研究表明， 增加的代谢需求，其他人认为，目前的方法， 计算能量消耗不充分，可能高估 需求 我们建议测量足月和早产儿的总能量消耗 婴儿使用双标记水的方法。 我们假设 患病早产儿和足月儿的能量消耗将大于 他们的稳定的同行。 我们希望能更准确地评估 这些婴儿的能量消耗和获得的信息 根据以下因素制定更适当的能量摄入建议： 胎龄和有无疾病