ENERGY REQUIREMENTS OF CRITICALLY ILL NEWBORNS

危重新生儿的能量需求

• 批准号: 6291128
• 负责人: CATHERINE LEITCH
• 金额: $ 0.04万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6291128
• 关键词: acute disease /disorder; bioenergetics; body weight; clinical research; gestational age; human subject; low birth weight infant human; newborn human (0-6 weeks); nutrition related tag

Optimal nutrition for the very low birthweight infant has yet to be established. Current recommendations for weight gain are based on in utero accretion rates without knowledge of exact energy requirements in these infants. Additional stressors are placed on both the ill preterm and term infants above their stable counterparts. Because of this, there has been a general consensus that the energy expenditure of these infants is correspondingly increased. Current studies to evaluate this issue have focused on older chronically ventilated infants rather then infants in the acute stages of illness. While some studies suggest a trend toward increased metabolic requirements, others suggest that current methods of calculating energy expenditure are inadequate and may be overestimating needs. We propose to measure total energy expenditure in term and preterm infants using the doubly labeled water method. We hypothesize that the energy expenditure of ill preterm and term infants will be greater than that of their stable counterparts. We hope to more accurately assess the energy expenditure of these infants and with the information obtained structure more appropriate recommendations for energy intake based on gestational age and presence or absence of illness.

极低出生体重婴儿的最佳营养尚未确定。目前的体重增加建议是基于子宫内的生长率，而不了解这些婴儿的确切能量需求。对患病的早产儿和足月儿施加的压力均高于稳定的婴儿。 正因为如此，人们普遍认为这些婴儿的能量消耗相应增加。 目前评估这一问题的研究主要集中在年龄较大的长期通气婴儿，而不是处于疾病急性期的婴儿。 虽然一些研究表明代谢需求有增加的趋势，但其他研究表明当前计算能量消耗的方法不足，并且可能高估了需求。 我们建议使用双标记水法来测量足月儿和早产儿的总能量消耗。 我们假设患病的早产儿和足月儿的能量消耗将高于稳定的婴儿。 我们希望更准确地评估这些婴儿的能量消耗，并根据所获得的信息，根据胎龄和是否患有疾病，提出更合适的能量摄入建议。