PYRIDOSTIGMINE INDUCED GROWTH HORMONE RESPONSE IN MOOD DISORDERS

大量研究表明，情感性精神障碍患者 有胆碱能过敏症。神经内分泌激发试验 为了测量它，使用了吡斯的明，它增加了胆碱能张力 在下丘脑，从而释放生长激素。这是一项单一的研究 表明可能患有双相情感障碍的患者有短暂的 在毒扁豆碱试验后，他们的思维障碍有所改善， 后来成为锂电池的响应者。我们想要检验的假设是 情感性精神障碍患者有胆碱能过敏和 确定这种假定的超敏感度是否为反应的标志 以及某些人格特征、心理感官体验和 挑战测试的结果。

Numerous studies have demostrated that patients with affective disorders have cholinergic supersensitivity. The neuroendocrine challenge test to measure it employs pyridostigmine, which increase cholinergic tone in the hypothalamus, thereby releasing GH. Thee is a single study indicating that the patients who were probably bipolar and had brief improvement in their thought disorders after a trial with physostigmine, went on to be lithium responders. We wish to test the hypothesis that patients with affective disorders have cholinergic supersensitivity and determine if this supposed supersensitivity is a marker of response as well as certain personality traits, psychosensory experience, and the results of the challenge test.