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FIBROBLAST GROWTH FACTOR AND BONE RESORPTION IN PATIENTS WITH BREAST CANCER

FIBROBLAST GROWTH FACTOR AND BONE RESORPTION IN PATIENTS WITH BREAST CANCER
乳腺癌患者的成纤维细胞生长因子和骨吸收
批准号:
6122693
负责人:
JONATHAN R SPORN
金额:
$1.91万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-01 至 1999-11-30

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中文摘要
翻译
该项目将测量乳腺癌患者的成纤维细胞生长因子(FGF)水平及其对骨转移的可能影响。研究者假设:1)骨转移的乳腺腺癌患者血清FGF水平高于无骨转移的患者和正常志愿者。这种差异是由于骨吸收过程中FGF-2的释放,以及2)骨转移患者的帕米膦酸盐治疗会通过抑制骨吸收来降低血清FGF水平。
英文摘要
This project will measure Fibroblast Growth Factor (FGF) levels in patients with breast cancer and their possible effects on bone metastasis. The investigators hypothesize that 1) serum FGF levels in patients with adenocarcinoma of the breast are greater in those with bone metastasis in comparison to those without bone metastasis and normal volunteers. This difference is due to the release of FGF-2 from resorbing bone, and, 2) that pamidronate therapy in patients with bone metastasis will decrease the serum levels of FGF by inhibiting bone resorption.
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Herbal Therapy for Hotflashes
PYRIDOSTIGMINE INDUCED GROWTH HORMONE RESPONSE IN MOOD DISORDERS
  • 批准号:
    6586409
  • 项目类别:
  • 资助金额:
    $20.08万
  • 财政年份:
    2002
  • 负责人:
    JONATHAN R SPORN
  • 依托单位:
PYRIDOSTIGMINE INDUCED GROWTH HORMONE RESPONSE IN MOOD DISORDERS
  • 批准号:
    6574376
  • 项目类别:
  • 资助金额:
    $20.08万
  • 财政年份:
    2001
  • 负责人:
    JONATHAN R SPORN
  • 依托单位:
TREATMENT OF INDOLENT B CELL LYMPHOMA & CLL PATIENTS W/ HEAT SHOCK PR
海外基金