PYRIDOSTIGMINE INDUCED GROWTH HORMONE RESPONSE IN MOOD DISORDERS

大量研究表明，情感性障碍患者存在胆碱能超敏反应。神经内分泌激发试验使用了吡斯的明，它能增加下丘脑的胆碱能张力，从而释放生长激素。这是一项单一的研究表明，那些可能患有双相情感障碍并在毒扁豆碱试验后思维障碍有短暂改善的患者，继续成为锂的反应者。我们希望检验情感障碍患者具有胆碱能超敏感的假设，并确定这种假设的超敏感是否是反应的标志，以及某些人格特征、心理感觉经验和挑战测试的结果。到目前为止，已有10名患者入选(3名对照和双相患者)。调查人员希望对这项研究进行修改。以便允许更多种类的患者进入方案。调查人员正在对议定书提出一项修正案，他们希望这将允许改善受试者的招募。虽然调查人员希望通过扩大纳入标准来改变方案，但实际的挑战测试本身将按照原始方案进行。

Numerous studies have demostrated that patients with affective disorders have cholinergic supersensitivity. The neuroendocrine challenge test to measure it employs pyridostigmine, which increase cholinergic tone in the hypothalamus, thereby releasing GH. This is a single study indicating that the patients who were probably bipolar and had brief improvement in their thought disorders after a trial with physostigmine, went on to be lithium responders. We wish to test the hypothesis that patients with affective disorders have cholinergic supersensitivity and determine if this supposed supersensitivity is a marker of response as well as certain personality traits, psychosensory experience, and the results of the challenge test. To date 10 patients have been enrolled (3 controls and bipolar). The investigators would like to make changes to this study. In order to allow for a greater variety of patients to enter the protocol. The investigators are proposing an amendment to the protocol that they hope will allow for improved recruitment of subjects. Although the investigators wish to change the protocol by broadening the inclusion criteria, the actual challenge test itself will be performed as per the original protocol.