PYRIDOSTIGMINE INDUCED GROWTH HORMONE RESPONSE IN MOOD DISORDERS

大量研究表明情感障碍患者 有胆碱能超敏反应神经内分泌激发试验 为了测量它，使用吡啶斯的明， 在下丘脑，从而释放生长激素。这是一项单一的研究 这表明那些可能患有双相情感障碍的患者 在试用毒扁豆碱后， 后来成为锂反应者。我们想验证一下这个假设， 情感障碍患者具有胆碱能超敏性， 确定这种所谓的超敏感性是否是反应的标志， 以及某些人格特征，心理感受体验， 挑战测试的结果。

Numerous studies have demostrated that patients with affective disorders have cholinergic supersensitivity. The neuroendocrine challenge test to measure it employs pyridostigmine, which increase cholinergic tone in the hypothalamus, thereby releasing GH. Thee is a single study indicating that the patients who were probably bipolar and had brief improvement in their thought disorders after a trial with physostigmine, went on to be lithium responders. We wish to test the hypothesis that patients with affective disorders have cholinergic supersensitivity and determine if this supposed supersensitivity is a marker of response as well as certain personality traits, psychosensory experience, and the results of the challenge test.