MENOPAUSE TRANSITION IN BLACK AND WHITE WOMEN--BONE DENSITY DIFFERENCE

目的：探讨绝经过渡期对黑人和白人妇女多种生理参数的影响。需要调查的核心参数包括更年期的流行病学(例如，绝经年龄和围绝经期的长度)、症状(潮热、情绪等)。心理社会和行为问题，更年期性行为的变化，以及更年期对卫生保健利用和健康相关行为的影响。需要研究的具体问题包括1)绝经对皮质骨和松质骨密度的影响；2)绝经对动脉壁厚度和顺应性的影响；3)维生素D受体(VDR)基因等位基因变异与基础骨密度和骨丢失率的关系；4)利用苗勒氏抑制物质(MIS)作为卵巢老化的新标志；以及5)使用雌激素活性的放射受体分析来帮助评估更年期症状的差异。除了评估更年期过渡对整个群体中这些参数的影响外，还对黑人和白人女性之间的这些参数进行了评估。协议已关闭，无法注册。这项研究是一项全国性多中心研究的一部分，数据分析目前还没有完成。

To investigate the effects of the menopause transition on a variety of physiological parameters in black and white women. Core parameters to be investigated include the epidemiology of the menopause (e.g. age of menopause and length of perimenopause), symptomatology (hot flashes, mood, etc.) psychosocial and behavioral issues, changes in sexual behavior across the menopause, and the effects of the menopause on health care utilization and health-related behaviors. Specific questions to be investigated include 1) the effects of the menopause on cortical and trabecular bone density; 2) the effects of the menopause on arterial wall thickness and compliance; 3) the relationship of allelic variation in the vitamin D receptor (VDR) genotype to baseline bone density and rates of bone loss; 4) the utility of utilizing Mullerian Inhibiting Substance (MIS) as a new marker of ovarian aging; and 5) use radioreceptor analyses of estrogenic activity to help assess differences in menopausal symptoms. In addition to assessing the impact of the menopause transition on these parameters in the group as a whole, a parameters between black and white women. Protocol is closed for enrollment. This study is part of a nation wide multicenter study and data analysis is not complete at this time.