SKELETAL EFFECTS OF BUFFER IN HIV INFECTION (PART B) ALSO SEE SPID 0698

缓冲液对 HIV 感染的骨骼影响（B 部分）另请参阅 SPID 0698

• 批准号: 7607064
• 负责人: Robert Marshall Neer
• 金额: $ 102.78万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607064
• 关键词: Acids; Antacids; Blood; Blood specimen; Buffers; Collection; Computer Retrieval of Information on Scientific Projects Database; Deglutition; Funding; Future; Grant; HIV Infections; Hour; Institution; Participant; Patients; Placebos; Potassium Chloride; Research; Research Personnel; Resources; Skeletal system; Source; Testing; Time; United States National Institutes of Health; Urine; Week; bone loss; bone metabolism; day; improved; potassium bicarbonate; prevent; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Volunteer patients with HIV infection and recent evidence of excess body acid swallow an inert material (placebo) 3 times a day with meals for 2 weeks. On 2 consecutive days at the end of each week, they save all their urine for 24 hours and bring it before breakfast to MGH, where they have morning blood collected. For the subsequent 2 weeks, they swallow either potassium bicarbonate (an antacid), potassium chloride (a non-antacid), or placebo (an inert material) 3 times a day with meals, and repeat the urine and blood collections as above at the end of each week. Which treatment a participant gets during this second 2 weeks is decided by lottery, and kept secret from the participants and investigators until the entire study is completed, to prevent accidentally-misleading results. By testing all the urine and blood samples, we can see whether neutralizing their excess body acid improved the participants' bone metabolism. If so, future more prolonged studies will test whether antacids prevent the bone loss that is so common in HIV-infected patients.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 最近有证据表明体内酸度过高的HIV感染志愿者每天随餐吞下一种惰性物质(安慰剂)3次，持续2周。在每周结束的连续两天，他们将所有的尿液保存24小时，并在早餐前将其带到MGH，在那里他们采集晨血。在接下来的两周里，他们每天三次随餐吞食碳酸氢钾(一种抗酸剂)、氯化钾(一种非抗酸剂)或安慰剂(一种惰性物质)，并在每周结束时重复上述尿液和血液收集。参与者在第二个2周内接受哪种治疗是通过抽签决定的，并对参与者和调查人员保密，直到整个研究完成，以防止意外误导结果。通过测试所有的尿样和血样，我们可以看到中和他们多余的体酸是否改善了参与者的骨骼代谢。如果是这样的话，未来更长时间的研究将测试抗酸剂是否能防止艾滋病毒感染患者常见的骨丢失。