SKELETAL EFFECTS OF BUFFER IN HIV INFECTION (PART B) ALSO SEE SPID 0698

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。最近有证据表明体内酸过多的HIV感染志愿者每天会随餐吞下一种惰性物质(安慰剂)3次，持续2周。在每周结束的连续两天，他们将保存所有的尿液24小时，并在早餐前将其带到MGH，在那里他们将采集晨血。在接下来的两周里，他们将每天三次随餐吞食碳酸氢钾(抗酸剂)、氯化钾(非抗酸剂)或安慰剂(一种惰性物质)，并在每周结束时重复上述尿液和血液收集。参与者在接下来的两周内接受哪种治疗将通过抽签决定，并对参与者和调查人员保密，直到整个研究完成，以防止意外误导结果。通过测试所有的尿样和血样，我们可以看到中和他们多余的体酸是否改善了参与者的骨骼代谢。如果是这样的话，未来更长时间的研究将测试抗酸剂是否能防止艾滋病毒感染患者常见的骨丢失。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Volunteer patients with HIV infection and recent evidence of excess body acid will swallow an inert material (placebo) 3 times a day with meals for 2 weeks. On 2 consecutive days at the end of each week, they will save all their urine for 24 hours and bring it before breakfast to MGH, where they will have morning blood collected. For the subsequent 2 weeks, they will swallow either potassium bicarbonate (an antacid), potassium chloride (a non-antacid), or placebo (an inert material) 3 times a day with meals, and repeat the urine and blood collections as above at the end of each week. Which treatment a participant gets during this second 2 weeks will be decided by lottery, and kept secret from the participants and investigators until the entire study is completed, to prevent accidentally-misleading results. By testing all the urine and blood samples, we can see whether neutralizing their excess body acid improved the participants' bone metabolism. If so, future more prolonged studies will test whether antacids prevent the bone loss that is so common in HIV-infected patients.