Physical Activity on Insulin Resistance in the Elderly

体力活动对老年人胰岛素抵抗的影响

• 批准号: 6431151
• 负责人: WIlliam J Evans
• 金额: $ 21.06万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6431151
• 关键词: aerobic exercise; aging; clinical research; glucose metabolism; hormone regulation /control mechanism; human old age (65+); human subject; insulin; insulin sensitivity /resistance

DESCRIPTION: (provided by applicant) Advancing age is associated with insulin resistance, glucose intolerance, and Type 2 diabetes. Regular higher-intensity aerobic exercise reduces insulin resistance and lowers the risk of Type 2 diabetes. Nonetheless, recent cross-sectional data, based on ACSM/CDC physical activity recommendations for moderate-intensity activity on most if not all days of the week (i.e., 1000 kcal/wk), demonstrate that insulin levels are lower with regular moderate-intensity activity in middle-aged adults, suggesting a reduction in insulin resistance. Despite these cross-sectional data, few well-controlled prospective studies have determined if these recommendations are appropriate to reduce insulin resistance in the elderly. Because higher-intensity aerobic exercise is not practical for a large percentage of the elderly, data are needed to determine the efficacy of moderate-intensity exercise on reducing insulin resistance. Therefore, the primary aim of this study will be to examine the influence of 1000 kcal/wk of moderate versus higher-intensity aerobic exercise on insulin-simulated glucose disposal. A secondary aim will examine if moderate and higher-intensity aerobic exercise differentially influence non-exercising activity. Recent data in the elderly suggest that regular higher-intensity activities may reduce non-exercising activity during rest of the day. We will recruit 57, 65-90 y old women and men, who will be randomized into one of the following three groups: 1) Moderate-intensity activity (1000 kcal/wk at 50 percent VO2peak; 2) Higher-intensity activity (1000 kcal/wk at 75 percent VO2peak); 3) Control. Subjects will complete 12 wk of aerobic cycling with pre and post-testing for insulin-stimulated glucose disposal via the hyperinsulinemic/euglycemic clamp, glucose tolerance by an OGTT, and body composition using dual energy x-ray absorptiometry. Physical activity levels will be assessed by structured questionnaire every 3 weeks. Our primary hypothesize is that 1000 kcal/wk of moderate or higher-intensity activity will be equally effective decreasing insulin resistance in the elderly. Our secondary hypothesis is that higher-intensity activity will decrease non-exercising physical activity in the elderly. This New Investigator application will provide data to base future aerobic exercise recommendations in elderly adults.

描述：（申请人提供）年龄增长与胰岛素相关 抵抗、葡萄糖耐受不良和2型糖尿病。常规高强度 有氧运动可以降低胰岛素抵抗，降低2型糖尿病的风险 糖尿病尽管如此，最近的横截面数据，根据ACSM/CDC的物理 中等强度活动的活动建议，如果不是全部的话， 一周中的几天（即，1000 kcal/wk），表明胰岛素水平 中年人定期进行中等强度活动时，该值较低， 表明胰岛素抵抗降低。尽管这些横截面 数据，很少有对照良好的前瞻性研究确定这些 建议适当降低老年人的胰岛素抵抗。 因为高强度的有氧运动对大部分人来说并不实用， 老年人的百分比，需要数据来确定 中等强度运动对降低胰岛素抵抗的作用。因此 本研究的主要目的是检查1000千卡/周的 中等强度与高强度有氧运动对胰岛素模拟葡萄糖的影响 处置第二个目标是检查中等强度和高强度的有氧运动 锻炼对非锻炼活动的影响不同。最近的数据在 老年人建议定期高强度活动可能会减少 在一天中的其他时间进行非运动性活动。我们将招募57，65-90岁 男性和女性，随机分为以下三组： 1)中等强度活动（1000 kcal/wk，50% VO 2峰值; 2） 高强度活动（1000千卡/周，75%的VO 2峰值）; 3）控制。 受试者将完成12周的有氧自行车运动，并进行以下方面的前后测试： 通过高胰岛素血症/正常血糖钳夹进行胰岛素刺激的葡萄糖处置， 通过OGTT测定葡萄糖耐量，使用双能X射线测定身体组成 吸收测定法身体活动水平将通过结构化的 每3周进行一次问卷调查。我们的主要假设是，1000千卡/周的 中等或更高强度的活动将同样有效地减少 老年人的胰岛素抵抗我们的第二个假设是 高强度的活动将减少非运动性的身体活动， 老人此新研究者应用程序将为未来的基础研究提供数据。 老年人的有氧运动建议。