Physical Activity on Insulin Resistance in the Elderly

描述：（由申请人提供）年龄增长与胰岛素有关 抵抗力、葡萄糖不耐受和 2 型糖尿病。定期较高强度 有氧运动可降低胰岛素抵抗并降低 2 型糖尿病的风险 糖尿病。尽管如此，最近基于 ACSM/CDC 物理的横截面数据 大多数（如果不是全部）中等强度活动的活动建议 一周中的几天（即 1000 kcal/周），证明胰岛素水平 中年成年人定期进行中等强度的活动则较低， 表明胰岛素抵抗减少。尽管有这些横截面 数据，很少有控制良好的前瞻性研究确定这些是否 建议适当减少老年人的胰岛素抵抗。 因为较高强度的有氧运动对于大人来说并不实用。 老年人的百分比，需要数据来确定效果 中等强度运动可降低胰岛素抵抗。因此， 本研究的主要目的是检查每周 1000 kcal 的热量的影响 中等强度与高强度有氧运动对胰岛素模拟血糖的影响 处置。次要目标将检查是否进行中等和较高强度的有氧运动 运动对非运动活动的影响存在差异。最近的数据在 老年人建议定期进行较高强度的活动可能会减少 一天其余时间进行非运动活动。我们将招募57、65-90岁 女性和男性，将被随机分为以下三组之一： 1) 中等强度活动（1000 kcal/周，50% VO2peak；2） 更高强度的活动（1000 kcal/周，75% VO2peak）； 3）控制。 受试者将完成 12 周的有氧循环，并进行前后测试 通过高胰岛素/正常血糖钳夹进行胰岛素刺激的葡萄糖处理， 通过 OGTT 测定葡萄糖耐量，并使用双能 X 射线测定身体成分 吸收测定法。身体活动水平将通过结构化评估 每 3 周进行一次调查问卷。我们的主要假设是每周 1000 kcal 中等或更高强度的活动同样有效地减少 老年人的胰岛素抵抗。我们的次要假设是 高强度的活动会减少非运动性体力活动 老人。这个新的调查员应用程序将为未来的基地提供数据 老年人有氧运动建议。

DESCRIPTION: (provided by applicant) Advancing age is associated with insulin resistance, glucose intolerance, and Type 2 diabetes. Regular higher-intensity aerobic exercise reduces insulin resistance and lowers the risk of Type 2 diabetes. Nonetheless, recent cross-sectional data, based on ACSM/CDC physical activity recommendations for moderate-intensity activity on most if not all days of the week (i.e., 1000 kcal/wk), demonstrate that insulin levels are lower with regular moderate-intensity activity in middle-aged adults, suggesting a reduction in insulin resistance. Despite these cross-sectional data, few well-controlled prospective studies have determined if these recommendations are appropriate to reduce insulin resistance in the elderly. Because higher-intensity aerobic exercise is not practical for a large percentage of the elderly, data are needed to determine the efficacy of moderate-intensity exercise on reducing insulin resistance. Therefore, the primary aim of this study will be to examine the influence of 1000 kcal/wk of moderate versus higher-intensity aerobic exercise on insulin-simulated glucose disposal. A secondary aim will examine if moderate and higher-intensity aerobic exercise differentially influence non-exercising activity. Recent data in the elderly suggest that regular higher-intensity activities may reduce non-exercising activity during rest of the day. We will recruit 57, 65-90 y old women and men, who will be randomized into one of the following three groups: 1) Moderate-intensity activity (1000 kcal/wk at 50 percent VO2peak; 2) Higher-intensity activity (1000 kcal/wk at 75 percent VO2peak); 3) Control. Subjects will complete 12 wk of aerobic cycling with pre and post-testing for insulin-stimulated glucose disposal via the hyperinsulinemic/euglycemic clamp, glucose tolerance by an OGTT, and body composition using dual energy x-ray absorptiometry. Physical activity levels will be assessed by structured questionnaire every 3 weeks. Our primary hypothesize is that 1000 kcal/wk of moderate or higher-intensity activity will be equally effective decreasing insulin resistance in the elderly. Our secondary hypothesis is that higher-intensity activity will decrease non-exercising physical activity in the elderly. This New Investigator application will provide data to base future aerobic exercise recommendations in elderly adults.