Physical Activity on Insulin Resistance in the Elderly

描述：(申请人提供)年龄增长与胰岛素有关 抵抗、葡萄糖不耐受和2型糖尿病。常规较高强度 有氧运动减少胰岛素抵抗，降低患2型的风险 糖尿病。尽管如此，最近的横截面数据，基于ACSM/CDC物理 对大多数(如果不是全部)中等强度活动的活动建议 一周中的几天(即1000千卡/周)，表明胰岛素水平是 较低的中年有规律的中等强度的活动， 这表明胰岛素抵抗的程度有所降低。尽管有这些横截面 数据，很少有良好控制的前瞻性研究确定这些 建议适当减少老年人的胰岛素抵抗。 因为高强度的有氧运动对 老年人的比例，需要数据来确定 中等强度运动对降低胰岛素抵抗的作用。因此， 这项研究的主要目的将是检查1000千卡/周的 中等强度有氧运动与大强度有氧运动对胰岛素模拟血糖的影响 处理完了。次要目标将检查中等强度和更高强度的有氧运动 运动对非运动活动的影响是不同的。最近公布的数据 老年人建议，定期高强度的活动可能会减少 在一天的其余时间进行非锻炼活动。我们将招募57，65-90岁的年轻人 女性和男性，他们将被随机分为以下三组之一： 1)中等强度的活动(1000kcal/wk，50%VO2峰值；2) 高强度活动(1000kcal/wk，75%VO2峰值)；3)对照组。 受试者将完成12周的有氧自行车，并进行前后测试 通过高胰岛素/正常血糖钳夹处理胰岛素刺激的葡萄糖， 用OGTT测定葡萄糖耐量，用双能x射线测定身体成分 吸光度测定法。体力活动水平将按结构进行评估 每3周进行一次问卷调查。我们的主要假设是1000千卡/周 中等强度或较高强度的运动将同样有效地减少 老年人中的胰岛素抵抗。我们的第二个假设是 高强度的运动会减少非运动性的体力活动 老年人。这个新的Investigator应用程序将为Base Future提供数据 建议老年人进行有氧运动。

DESCRIPTION: (provided by applicant) Advancing age is associated with insulin resistance, glucose intolerance, and Type 2 diabetes. Regular higher-intensity aerobic exercise reduces insulin resistance and lowers the risk of Type 2 diabetes. Nonetheless, recent cross-sectional data, based on ACSM/CDC physical activity recommendations for moderate-intensity activity on most if not all days of the week (i.e., 1000 kcal/wk), demonstrate that insulin levels are lower with regular moderate-intensity activity in middle-aged adults, suggesting a reduction in insulin resistance. Despite these cross-sectional data, few well-controlled prospective studies have determined if these recommendations are appropriate to reduce insulin resistance in the elderly. Because higher-intensity aerobic exercise is not practical for a large percentage of the elderly, data are needed to determine the efficacy of moderate-intensity exercise on reducing insulin resistance. Therefore, the primary aim of this study will be to examine the influence of 1000 kcal/wk of moderate versus higher-intensity aerobic exercise on insulin-simulated glucose disposal. A secondary aim will examine if moderate and higher-intensity aerobic exercise differentially influence non-exercising activity. Recent data in the elderly suggest that regular higher-intensity activities may reduce non-exercising activity during rest of the day. We will recruit 57, 65-90 y old women and men, who will be randomized into one of the following three groups: 1) Moderate-intensity activity (1000 kcal/wk at 50 percent VO2peak; 2) Higher-intensity activity (1000 kcal/wk at 75 percent VO2peak); 3) Control. Subjects will complete 12 wk of aerobic cycling with pre and post-testing for insulin-stimulated glucose disposal via the hyperinsulinemic/euglycemic clamp, glucose tolerance by an OGTT, and body composition using dual energy x-ray absorptiometry. Physical activity levels will be assessed by structured questionnaire every 3 weeks. Our primary hypothesize is that 1000 kcal/wk of moderate or higher-intensity activity will be equally effective decreasing insulin resistance in the elderly. Our secondary hypothesis is that higher-intensity activity will decrease non-exercising physical activity in the elderly. This New Investigator application will provide data to base future aerobic exercise recommendations in elderly adults.