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Physical Activity on Insulin Resistance in the Elderly

体力活动对老年人胰岛素抵抗的影响

基本信息

批准号：
6649672
负责人：
WIlliam J Evans
金额：
$ 21.06万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-30 至 2005-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6649672
关键词：
aerobic exercise aging clinical research glucose metabolism hormone regulation /control mechanism human old age (65+) human subject insulin insulin sensitivity /resistance

项目摘要

DESCRIPTION: (provided by applicant) Advancing age is associated with insulin resistance, glucose intolerance, and Type 2 diabetes. Regular higher-intensity aerobic exercise reduces insulin resistance and lowers the risk of Type 2 diabetes. Nonetheless, recent cross-sectional data, based on ACSM/CDC physical activity recommendations for moderate-intensity activity on most if not all days of the week (i.e., 1000 kcal/wk), demonstrate that insulin levels are lower with regular moderate-intensity activity in middle-aged adults, suggesting a reduction in insulin resistance. Despite these cross-sectional data, few well-controlled prospective studies have determined if these recommendations are appropriate to reduce insulin resistance in the elderly. Because higher-intensity aerobic exercise is not practical for a large percentage of the elderly, data are needed to determine the efficacy of moderate-intensity exercise on reducing insulin resistance. Therefore, the primary aim of this study will be to examine the influence of 1000 kcal/wk of moderate versus higher-intensity aerobic exercise on insulin-simulated glucose disposal. A secondary aim will examine if moderate and higher-intensity aerobic exercise differentially influence non-exercising activity. Recent data in the elderly suggest that regular higher-intensity activities may reduce non-exercising activity during rest of the day. We will recruit 57, 65-90 y old women and men, who will be randomized into one of the following three groups: 1) Moderate-intensity activity (1000 kcal/wk at 50 percent VO2peak; 2) Higher-intensity activity (1000 kcal/wk at 75 percent VO2peak); 3) Control. Subjects will complete 12 wk of aerobic cycling with pre and post-testing for insulin-stimulated glucose disposal via the hyperinsulinemic/euglycemic clamp, glucose tolerance by an OGTT, and body composition using dual energy x-ray absorptiometry. Physical activity levels will be assessed by structured questionnaire every 3 weeks. Our primary hypothesize is that 1000 kcal/wk of moderate or higher-intensity activity will be equally effective decreasing insulin resistance in the elderly. Our secondary hypothesis is that higher-intensity activity will decrease non-exercising physical activity in the elderly. This New Investigator application will provide data to base future aerobic exercise recommendations in elderly adults.

描述：（由申请人提供）年龄增长与胰岛素有关抵抗力、葡萄糖不耐受和 2 型糖尿病。定期较高强度有氧运动可降低胰岛素抵抗并降低 2 型糖尿病的风险糖尿病。尽管如此，最近基于 ACSM/CDC 物理的横截面数据大多数（如果不是全部）中等强度活动的活动建议一周中的几天（即 1000 kcal/周），证明胰岛素水平中年成年人定期进行中等强度的活动则较低，表明胰岛素抵抗减少。尽管有这些横截面数据，很少有控制良好的前瞻性研究确定这些是否建议适当减少老年人的胰岛素抵抗。因为较高强度的有氧运动对于大人来说并不实用。老年人的百分比，需要数据来确定效果中等强度运动可降低胰岛素抵抗。因此，本研究的主要目的是检查每周 1000 kcal 的热量的影响中等强度与高强度有氧运动对胰岛素模拟血糖的影响处理。次要目标将检查是否进行中等和较高强度的有氧运动运动对非运动活动的影响存在差异。最近的数据在老年人建议定期进行较高强度的活动可能会减少一天其余时间进行非运动活动。我们将招募57、65-90岁女性和男性，将被随机分为以下三组之一： 1) 中等强度活动（1000 kcal/周，50% VO2peak；2）更高强度的活动（1000 kcal/周，75% VO2peak）； 3）控制。受试者将完成 12 周的有氧循环，并进行前后测试通过高胰岛素/正常血糖钳夹进行胰岛素刺激的葡萄糖处理，通过 OGTT 测定葡萄糖耐量，并使用双能 X 射线测定身体成分吸收测定法。身体活动水平将通过结构化评估每 3 周进行一次调查问卷。我们的主要假设是每周 1000 kcal 中等或更高强度的活动同样有效地减少老年人的胰岛素抵抗。我们的次要假设是高强度的活动会减少非运动性体力活动老年。这个新的调查员应用程序将为未来的基地提供数据老年人有氧运动建议。