Physical Activity on Insulin Resistance in the Elderly
体力活动对老年人胰岛素抵抗的影响
基本信息
- 批准号:6649672
- 负责人:
- 金额:$ 21.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-09-30 至 2005-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: (provided by applicant) Advancing age is associated with insulin
resistance, glucose intolerance, and Type 2 diabetes. Regular higher-intensity
aerobic exercise reduces insulin resistance and lowers the risk of Type 2
diabetes. Nonetheless, recent cross-sectional data, based on ACSM/CDC physical
activity recommendations for moderate-intensity activity on most if not all
days of the week (i.e., 1000 kcal/wk), demonstrate that insulin levels are
lower with regular moderate-intensity activity in middle-aged adults,
suggesting a reduction in insulin resistance. Despite these cross-sectional
data, few well-controlled prospective studies have determined if these
recommendations are appropriate to reduce insulin resistance in the elderly.
Because higher-intensity aerobic exercise is not practical for a large
percentage of the elderly, data are needed to determine the efficacy of
moderate-intensity exercise on reducing insulin resistance. Therefore, the
primary aim of this study will be to examine the influence of 1000 kcal/wk of
moderate versus higher-intensity aerobic exercise on insulin-simulated glucose
disposal. A secondary aim will examine if moderate and higher-intensity aerobic
exercise differentially influence non-exercising activity. Recent data in the
elderly suggest that regular higher-intensity activities may reduce
non-exercising activity during rest of the day. We will recruit 57, 65-90 y old
women and men, who will be randomized into one of the following three groups:
1) Moderate-intensity activity (1000 kcal/wk at 50 percent VO2peak; 2)
Higher-intensity activity (1000 kcal/wk at 75 percent VO2peak); 3) Control.
Subjects will complete 12 wk of aerobic cycling with pre and post-testing for
insulin-stimulated glucose disposal via the hyperinsulinemic/euglycemic clamp,
glucose tolerance by an OGTT, and body composition using dual energy x-ray
absorptiometry. Physical activity levels will be assessed by structured
questionnaire every 3 weeks. Our primary hypothesize is that 1000 kcal/wk of
moderate or higher-intensity activity will be equally effective decreasing
insulin resistance in the elderly. Our secondary hypothesis is that
higher-intensity activity will decrease non-exercising physical activity in the
elderly. This New Investigator application will provide data to base future
aerobic exercise recommendations in elderly adults.
描述:(由申请人提供)年龄增长与胰岛素有关
抵抗力、葡萄糖不耐受和 2 型糖尿病。定期较高强度
有氧运动可降低胰岛素抵抗并降低 2 型糖尿病的风险
糖尿病。尽管如此,最近基于 ACSM/CDC 物理的横截面数据
大多数(如果不是全部)中等强度活动的活动建议
一周中的几天(即 1000 kcal/周),证明胰岛素水平
中年成年人定期进行中等强度的活动则较低,
表明胰岛素抵抗减少。尽管有这些横截面
数据,很少有控制良好的前瞻性研究确定这些是否
建议适当减少老年人的胰岛素抵抗。
因为较高强度的有氧运动对于大人来说并不实用。
老年人的百分比,需要数据来确定效果
中等强度运动可降低胰岛素抵抗。因此,
本研究的主要目的是检查每周 1000 kcal 的热量的影响
中等强度与高强度有氧运动对胰岛素模拟血糖的影响
处理。次要目标将检查是否进行中等和较高强度的有氧运动
运动对非运动活动的影响存在差异。最近的数据在
老年人建议定期进行较高强度的活动可能会减少
一天其余时间进行非运动活动。我们将招募57、65-90岁
女性和男性,将被随机分为以下三组之一:
1) 中等强度活动(1000 kcal/周,50% VO2peak;2)
更高强度的活动(1000 kcal/周,75% VO2peak); 3)控制。
受试者将完成 12 周的有氧循环,并进行前后测试
通过高胰岛素/正常血糖钳夹进行胰岛素刺激的葡萄糖处理,
通过 OGTT 测定葡萄糖耐量,并使用双能 X 射线测定身体成分
吸收测定法。身体活动水平将通过结构化评估
每 3 周进行一次调查问卷。我们的主要假设是每周 1000 kcal
中等或更高强度的活动同样有效地减少
老年人的胰岛素抵抗。我们的次要假设是
高强度的活动会减少非运动性体力活动
老年。这个新的调查员应用程序将为未来的基地提供数据
老年人有氧运动建议。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Effects of exercise on senescent muscle.
运动对衰老肌肉的影响。
- DOI:10.1097/00003086-200210001-00025
- 发表时间:2002
- 期刊:
- 影响因子:4.2
- 作者:Evans,WilliamJ
- 通讯作者:Evans,WilliamJ
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{{ truncateString('WIlliam J Evans', 18)}}的其他基金
Nutritional needs of elderly people in long-term care
长期护理老年人的营养需求
- 批准号:
6888401 - 财政年份:2005
- 资助金额:
$ 21.06万 - 项目类别:
Physical Activity on Insulin Resistance in the Elderly
体力活动对老年人胰岛素抵抗的影响
- 批准号:
6431151 - 财政年份:2001
- 资助金额:
$ 21.06万 - 项目类别:
Physical Activity on Insulin Resistance in the Elderly
体力活动对老年人胰岛素抵抗的影响
- 批准号:
6532563 - 财政年份:2001
- 资助金额:
$ 21.06万 - 项目类别:
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