Dissecting the molecular mechanisms during reprogramming of different somatic cells into induced pluripotent stem cells and the plasticity potential of their intermediate stages.

剖析不同体细胞重编程为诱导多能干细胞过程中的分子机制及其中间阶段的可塑性潜力。

• 批准号: nhmrc : 1036587
• 负责人: A/Pr Jose Polo
• 金额: $ 15.67万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-molecular-mechanisms-intermediate-stages/111023
• 关键词: Dissecting; molecular; mechanisms; during; reprogramming

I am a biochemist interested in the molecular mechanisms involved in gene expression and how these processes govern cell identity. I use a combination of mouse models, biochemical techniques and bioinformatics to study the _reprogramming� of adult cells into embryonic stem-like cells and how this technology can be used to generate different cell types for use in cellular replacement therapies and drug screening.

我是一名生物化学家，对基因表达的分子机制以及这些过程如何控制细胞身份感兴趣。我使用小鼠模型，生化技术和生物信息学的组合来研究成人细胞重新编程为胚胎干细胞样细胞，以及如何使用这种技术来产生不同的细胞类型，用于细胞替代疗法和药物筛选。