Repair of epigenetic abnormalities in human induced pluripotent stem cells by targeted epigenome engineering

通过靶向表观基因组工程修复人类诱导多能干细胞的表观遗传异常

• 批准号: nhmrc : 1069830
• 负责人: A/Pr Jose Polo
• 金额: $ 54.04万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/repair-epigenetic-abnormalities-epigenome-engineering/455412
• 关键词: Repair; epigenetic; abnormalities; human; induced

New advances enable a patient’s cells to be reprogrammed into an adult stem cell, with the capacity to turn into any specialized cell type to replace a patient’s damaged cells. However, we have discovered that adult stem cells are flawed, they have an epigenetic memory of their past specialized form that limits their capacity to transform into other specialized cells. We will use a novel molecular tool to erase this memory, thus repairing adult stem cells for their use in regenerative medicine.

新的进展使患者的细胞能够被重新编程为成体干细胞，并能够转变为任何特殊的细胞类型来替代患者受损的细胞。然而，我们发现成体干细胞是有缺陷的，它们对过去的特殊形式有表观遗传记忆，这限制了它们转化为其他特殊细胞的能力。我们将使用一种新颖的分子工具来消除这种记忆，从而修复成体干细胞以用于再生医学。