Does nuclear reprogramming of granulocytes induce reversal of the hematopoiesis pathway.

粒细胞的核重编程是否会导致造血途径逆转？

• 批准号: nhmrc : 1051309
• 负责人: A/Pr Jose Polo
• 金额: $ 30.79万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-nuclear-reprogramming-hematopoiesis-pathway/112209
• 关键词: Does; nuclear; reprogramming; granulocytes; induce

Generation of induced pluripotent stem cells has enormous therapeutic potential. However, it is unclear whether de-differentiation to pluripotency proceeds via a reversion of the same developmental pathway that gave rise to the cell type being reprogrammed. To answer this we will dissect the reprogramming process within the well defined hematopoietic system and assess the generation of hematopoietic precursor-like cells during reprogramming.

诱导多能干细胞的产生具有巨大的治疗潜力。然而，目前尚不清楚去分化为多能性是否通过逆转引起细胞类型重编程的相同发育途径进行。为了回答这个问题，我们将解剖在明确定义的造血系统内的重编程过程，并评估在重编程过程中造血干细胞样细胞的产生。