Exploring and Targeting the Anti-Inflammatory Signalling Mechanisms of Interleukin 37

探索和靶向白细胞介素 37 的抗炎信号传导机制

• 批准号: nhmrc : 1140820
• 负责人: A/Pr Jose Polo
• 金额: $ 68.85万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-targeting-anti-interleukin-37/1319320
• 关键词: Exploring; Targeting; Anti; Inflammatory; Signalling

Cytokines are messenger proteins that function as master regulators of biological processes; thus they play central roles in many diseases. The rare cytokines that block inflammation do so by dampening the immune system’s potentially destructive force, making them attractive targets for drug development. We showed that interleukin 37 is a powerful anti-inflammatory cytokine, and will now evaluate its mechanisms of action and its efficacy against several severe diseases, including cancer.

细胞因子是作为生物过程的主要调节剂发挥功能的信使蛋白;因此它们在许多疾病中发挥核心作用。罕见的细胞因子通过抑制免疫系统的潜在破坏力来阻止炎症，使它们成为药物开发的有吸引力的目标。我们发现白细胞介素37是一种强大的抗炎细胞因子，现在将评估其作用机制及其对几种严重疾病（包括癌症）的疗效。