Leveraging genomics strategies to generate adult neurons from iPSCs and somatic cells

利用基因组学策略从 iPSC 和体细胞生成成体神经元

• 批准号: nhmrc : 1130168
• 负责人: A/Pr Jose Polo
• 金额: $ 108.91万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/leveraging-genomics-strategies-somatic-cells/948526
• 关键词: Leveraging; genomics; strategies; generate; adult

Recent advances have made it possible to derive myriad specialized human cells from stem cells or by directly reprogramming cell identity. However, these derived cells are generally arrested at a fetal developmental stage, and do not mature to function like adult cells. We will use new genomic, epigenetic, cell reprogramming, and manipulation methods to discover how to derive mature cells, aiming to generate mature neurons for use in neurobiology research, disease modeling, and drug screening.

最近的进展使从干细胞或通过直接对细胞身份重新编程来获得无数专门的人类细胞成为可能。然而，这些来源的细胞通常在胎儿发育阶段被阻止，不会成熟到像成年细胞一样发挥功能。我们将使用新的基因组、表观遗传学、细胞重新编程和操作方法来发现如何获得成熟细胞，旨在生成成熟神经元，用于神经生物学研究、疾病建模和药物筛选。